Podcast Episodes

ImmunoEpigeneticsXXXII. Apriori synthesis of the glycolytic/TCA/ETC axis mediating target and endogenous apoptotic control with Th and NK cell activation/proliferation and effector function. DJGPhD.

References

 Authentic Biochemistry Podcast  Immunoepigenetics lectures XXIX-XXX1

Dr. Guerra's intermediary metabolism and bioenergetics lectures

Natu…

3 years, 8 months ago

ImmunoEpigenetics XXXI. The role of SDH on Complex II electron flow to ubiquinone subsequent to cardiac arrest is associated neuronal PCD similar to Tcell bioenergetic switching during activation.

References

J of Intensive Care. 2020. volume 8, Article number: 60.

Neuroscience. 2018 Nov 21;393:24-32

Cancers 2020, 12(11), 3237

Nature. 2019 Jul; …

3 years, 8 months ago

Immunoepigenetics XXX.NK lymphoyctes programed tumor cell death by titrating anti-apoptotic BCL proteins with BH3 pro-apoptotic events. DJGPhD. 17.2.23. Authentic Biochemistry Podcast

References

Cancers (Basel). 2020 Aug; 12(8): 2137.

Cell Death Dis. 2020 Jan 2;11(1):5

Cell. 2022. 185. 9. :521-1538.e18

3 years, 8 months ago

ImmunoEpigenetics XXIX. Apoptosis unthwarted:preventing phosphorylation of RNAPOLII tanks histone acetylation near Mcl enhancer region thus epigenetically inhibiting expression in glioblastoma cells.

References

Cell Death & Differentiation 2020.27: 3374–3385 

Cell Death & Differentiation 2019. 26: 1501–1515

Cancers  2020, 12(8), 2137.

3 years, 8 months ago

A Dialectic on Research Scientific Method I. How research questions may be apprehended through the hypothetico-deductive-experimental paradigm. DJGPhD. 14.2.23

References

Guerra: lectures on research methods

3 years, 8 months ago

ImmunoEpigenetics XXVIII, Synthesis of epigenetically controlled ferroptosis with Cyto-Toxic T Lymphocyte APC/MHC activated IFN-Gamma induced tumor fatty acyl CoA synthase- lipid peroxide mechanism.

References

Cancer Cell  2020. 40, Issue 4, Pages 365-378.e6

Circulation Research. . 2004 May 28;94(10):1318-24.

Mol Cell. 2020 Jun 18;78(6):1192-1206…

3 years, 8 months ago

Immunoepigenetics XXVII. PKM2 as an epigenetic and metabolic author of cell proliferation leading to tumorigenesis. DJGPhD. 12 Feb 2023. Authentic Biochemistry Podcast

References

Mol Cell. 2014 Mar 6;53(5):700-9

Mol Cell. 2015 Sep 3;59(5):850-7

Cell & Bioscience 2019.Volume 9, Article number: 52.

3 years, 8 months ago

ImmunoEpigenetics XXVI.The repressive deubiquitinase (PR-DUB) inhibits ubiquitinated histone 2A occupancy on SLC7A11 promoter causing cystine starvation and GSH depletion promoting ferroptosis. DJGPhD

References

Cell Research. 2022. volume 32, pages 687–690 .

3 years, 8 months ago

ImmunoEpigenetics XXV. Lymphocyte Specific Helicase inhibits ferroptosis while promoting tumorigenesis via fatty acid desaturase gene transcription and subsequent oleic acid formation via CoQ10.DJGPhD

References

Molecular Cancer 2020. volume 19, Article number: 39. 

Adv Exp Med Biol. 2021; 1301:41-57

3 years, 8 months ago

A Biochemical Partita 7th Movement. The articulation of obesity as arbiter of pathophysiology. DJGPhD. 04Feb23. Authentic Biochemistry.

References and Inspiration

Dr Guerra lecture notes

https://youtu.be/uubKzLxxj1s

3 years, 8 months ago