Podcast Episodes

ImmunoEpigenetics 53.The metaphysics of biochemical control within epigenetic alteration of gene expression as obtained in macrophage mediated immune activation. DJGPhD.7April23'Authentic Biochem

References

Dr Guerra's lecture notes-Immunology

DJGPhD writings on Middle Platonist Metaphysics in Biochemistry: unpublished

Curr Opin Biotechnol. 2…

3 years, 6 months ago

ImmunoEpigenetics 52. Integration of intermediary metabolism with epigenetic modification of immune cell activation and proliferation.DJGPhD. 5April23. Authentic Biochemistry Podcast.

References

Curr Opin Biotechnol. 2020 Jun; 63: 111–117

Epigenomics. 2019. VOL. 11, NO. 68 May

Front.Genet., 23 October 2018 Sec. Epigenomics and Epig…

3 years, 6 months ago

ImmunoEpigenetics 51. The Glutamine contribution to tumor bioenergetics and lipogenesis and the role of storage TAG in macrophage pro-inflammation. DJGPhD. 29.3.23

References

Nature Communications 2020.volume 11, Article number: 4107.

Nutrire 2016. volume 41, Article number: 14

3 years, 6 months ago

ImmunoEpigenetics 50. Malic Enzyme serves as a cytosolic circuit to generate pyruvate from glutamine to drive cancer cell division by altering TCA flux and indirectly, cell cycle progression.DJGPhD

References

Cell 2012 148DOI: (10.1016/j.cell.2012.01.031)

Biotechnology Journal 2016. Volume11, Issue1 Special Issue: Biotech Methods and Advances: …

3 years, 7 months ago

ImmunoEpigenetics49.SiRNA knockdown of ME1 increases Haeme Oxygenase activity in both glucose supplemented and deprived cancer cells. The Pseudoparadox of epigenetic control over metabolism. DJGPhD

References

Dr Guerra's lectures and spontaneous expectorations.

Molecular Cancer 2020. volume 19, Article number: 39

3 years, 7 months ago

ImmunoEpigenetics48. Importance of malic enzyme isoform subcellular distribution using 13CNMR -U13C C6 glucose isotopomer detection of pathway intermediates:GSIS vs. cancer.DJGPhD.21.3.23

References

Methods Enzymol. 2009; 457: 425–450

Endocrinology, Volume 155, Issue 5, 1 May 2014, Pages 1653–1666

Am J Physiol Endocrinol Metab. 2008 De…

3 years, 7 months ago

Immunoepigenetics 47. Intermediary metabolism re-enters the discussion on tumor corruption of cell division via diversion of glucose to NADPH production.DJGPhD

References

Dr Guerra's lectures

AJP Endocrinology and Metabolism. 2008. 295(6):E1287-97   

Biochem Biophys Res Commun.1996 May 15;222(2):287-91

Carc…

3 years, 7 months ago

ImmunoEpigenetics 46.The Keap1/Nrf2/MAF axis in colorectal cancer: Methylation specific promoter mediated expression of anti-oxidant genes unveiling a complex role in tumorigenesis.DJGPhD.15.3.23

References

Carcinogenesis. 2020 Jun; 41(4): 405–416

Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39

3 years, 7 months ago

ImmunoEpigenetics 45. Innate immune cell nSMASE generates ceramide mediated TLR signalling epigenetic alterations resulting in COX-2 electrophile PG- Michael adduct removal of KEAP/Nrf2 association.

References

Carcinogenesis. 2020 Jun; 41(4): 405–416

Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39

3 years, 7 months ago

ImmunoEpigenetics 44. Ceramide and NRF2 mediate oxygen stress and the pro-inflammatory cytokine respose via association with chromatin epigenetic retailoring. DJGPhD.8March23. Authentic Biochemistry.

References

Antioxidants (Basel). 2023 Feb; 12(2): 274

J Lipid Res. 2016 May; 57(5): 868–881.

J Biol Chem. 2007 Jan 12;282(2):1384-96.

J. Am. Chem. So…

3 years, 7 months ago