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ImmunoEpigenetics 69. Lipoprotein and cargo cholesterol in the epigenetic regulation of the tumor microenvironment secreted pleckstrin convertase corrupting CD8+ Tcell cholesterol uptake and potency.
References
Journal of Experimental & Clinical Cancer Research 2022.volume 41, Article number: 303.
Protein Cell. 2021 Apr; 12(4): 240–260.
J Cell Bi…
3 years, 5 months ago
Graduate Biochemistry Lecture III. Dietary lipid control over neuroendocrine system involves multiple organ systems in contact with immune surveilance. DJGPhD. 24.5.23B Authentic Biochemistry
References
Dr. Guerra's lecture archives.
3 years, 5 months ago
Graduate Biochemistry Lecture.II. Lipid digestion and enterocyte localized neuroendocrine secretion proximal to chylomicron assembly.Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.
References
Dr. Guerra's lipid lectures
J Diabetes Investig. 2019 Nov; 10(6): 1430–1437.
3 years, 5 months ago
Special Graduate Biochemistry Lecture! Lipoproteins I. Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.
Reference
Dr Guerra: Graduate Biochemistry lecture material.
3 years, 5 months ago
ImmunoEpigenetics 68. Closure on atherosclerosis and CVD linking transcription factors and membrane receptors to oxidation of PUFA's and oxysterol resulting in methylation of ABCG and SREB promoters
References
Arterioscler Thromb Vasc Biol . 2021 Jan;41(1):153-166.
Clinical Epigenetics 2021. volume 13, Article number: 7.
https://www.sciencedire…
3 years, 5 months ago
ImmunoEpigenetics 67. Pathobiochemical alteration of cholesterol oxides mediated via cytochrome P450 and dehydro -reductases link atherosclerosis and the CTX/SLO motor neuron diseases. DJGPhD
References
JLR 2014 55(6) Pages 1165-1172.
JLR 2018 59(6): 1058–1070.
3 years, 5 months ago
ImmunoEpigenetics 66. The NOX/PHOX/DUOX enzymes in atherosclerosis, thyroid hormonogenesis and thyroid tumorigenesis. An epigenetic telos from oxidized lipid to altered transcription patterns.DJGPhD.
References
PLoS ONE 2012. 7(4): e3440
Steroids 2021. Volume 172, August, 108854
Antioxidants 2019, 8(5), 126
3 years, 5 months ago
ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis.
References
Free Radical Biology and Medicine
Volume 71, June. Pages 1-15
Cardiovasc.Res. 2012 May 1; 94(2): 379–390.
Int. J. Mol. Sci. 2020, 21(…
3 years, 5 months ago
ImmunoEpigenetics65A. Micro-RNA mediated cancellation of mitochondrial NADPH-producing Isocitrate Dehydrogenase 2is controlled by 7-Keto cholesterol. DJGPhD 12May2023. Authentic Biochemistry Podcast
References
Free Radical Biology and Medicine
Volume 71, Pages 1-15
Steroids. 2021 Aug; 172:108854.
3 years, 5 months ago
ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means
References
Free Radical Biology and Medicine 2014. Volume 71, June.Pages 1-15
J Mol Endocrinol. 2020 Nov; 65(4): R77–R90.
REDOX and Cholesterol meta…
3 years, 5 months ago