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T-lymphocyte and macrophage membrane CD38 ecto-enzyme mediated NAD catabolism is associated with ageing and the decline in Sirtuin-mediated deacylase activity. DJGPhD.11.Dec.21' Authentic Biochemistry
References
Cell Metabolism. 2016. 23, 1127–1139
Cells 2020, 9(1), 228
Front. Immunol., 31 May 2019
Int J Mol Sci. 2020 Nov; 21(22): 8609
Circ Res. 20…
4 years, 5 months ago
Aposteriori synthesis of neuroendocrine linked clock chronicity and the Senescent associated Secretory Phenotype through the synthetic apriori lens of NAD+. DJGPhD.10Dec21. Authentic Biochemistry
References
Nat Cell Biol. 2019 Mar; 21(3): 397–407
J Diabetes Metab Disord. 2020 Jul 21;19(2):1797-1825
Int. J. Mol. Sci. 2014, 15, 16848-16884
4 years, 5 months ago
How testosterone-aromatase derived estradiol transformation to 2-methoxy-17beta-estradiol can mitigate cell proliferation by promoting a senescent phenotype.DJGPhD. Authentic Biochemistry.8.DEC.21
Besides 2-methoxy-17beta-estradiol, cell cycle arrest via chromatin deacetylation can mitigate cell proliferation by decreasing global transcription…
4 years, 5 months ago
Blocking cellular senescence may suppress autoimmune diseases and reactive oxygen mediated cell death but non-ironically promote oncogenesis and tumor development during ageing. DJGPhD. 06.DEC.21
Cell fate from Either ageing associated senescence to programmed cell death OR cell proliferation is finely tuned to the splice variant expression o…
4 years, 5 months ago
Ageing and Asymmetric Dimethylarginine (ADMA)in Endothelial Nitric Oxide Synthase inhibition-associated decrease in respiratory vasodilation. Dr Dan Guerra 24.11.21 Authentic Biochemistry
Age Ageing, Volume 48, Issue 6, November 2019, Pages 776–782
Biomedicines. 2020 Aug 6;8(8):277
4 years, 5 months ago
Closing the window and drawing the curtain: cancer phenotypes are resolute signatures of Immunosenescence and inflammaging induced epigenetic collapse of vital biochemical homeostasis. DJGPhD.20/11/21
Dr. Guerra authentically arrives at the inveighing cancer paradigm contribution to the sickness unto death.
4 years, 6 months ago
Sealing Fate: Immunosenescent and inflammatory mechanisms combine the ineffectual with the increscent pathophysiology of sickness unto death. DJGPhD. 17.11.21
Nutrients. 2020 Mar; 12(3): 622.
Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019. pp 21-43.The Immune System and Its Dysregul…
4 years, 6 months ago
The interplay between Immunosenescence and inflammaging conduct the innate and acquired immune response toward functional cellular rigidity and incompetence obtaining morbidity and mortality. DJGPhD.
1.Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019. pp 21-43. The Immune System and Its Dysregulation with Aging. Ludmila Mül…
4 years, 6 months ago
Fine detail of Treg cell control over inflammation suppression via FoxP3 transcriptional modulation. Aging and Obesity will limit this control leading to hyperinflammation. DJGPhD. 08Nov2021
References
Front. Immunol., 29 June 2012
J Immunol 2016;197:3762-3770
Front. Immunol., 03 February 2020
4 years, 6 months ago
T cell receptor signaling kinase dynamics after APC activation. Co-activating CD28 becomes deficient via immunosenescence thus corrupting T cell efficiency in the elderly. 26.10.2021 DJGPhD.
The Src-family kinase Lck regulates T-cell development, activation, proliferation, and immune synapse dynamics. These are the initiation phases of TC…
4 years, 6 months ago