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ImmunoEpigenetics65A. Micro-RNA mediated cancellation of mitochondrial NADPH-producing Isocitrate Dehydrogenase 2is controlled by 7-Keto cholesterol. DJGPhD 12May2023. Authentic Biochemistry Podcast
References
Free Radical Biology and Medicine
Volume 71, Pages 1-15
Steroids. 2021 Aug; 172:108854.
3 years, 5 months ago
ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means
References
Free Radical Biology and Medicine 2014. Volume 71, June.Pages 1-15
J Mol Endocrinol. 2020 Nov; 65(4): R77–R90.
REDOX and Cholesterol meta…
3 years, 5 months ago
ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites
References
Cancers (Basel). 2019 May; 11(5): 678.
Oncogene.2017 Mar 23; 36(12): 1607–1618
Dr Guerra's annotated lecture notes from graduate biochemi…
3 years, 5 months ago
ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD
References
Front. Cell Dev. Biol., 26 March2021 Sec. Molecular and Cellular Oncology Volume 9
Cancer Drug Resist 2020;3:762-74.
Oncogene.2017 Mar 23…
3 years, 5 months ago
ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability.
References
Dr Guerra Intermediary metabolic lecture notes-graduate biochemistry lecture archives
Epigenetics. 2019; 14(12): 1183–1193.
Drug Discov T…
3 years, 5 months ago
Immunoepigenetics 60. LOH of PHLDA3 confers wt allelic methylation and loss of activity in pancreatic neuroendocrine tumorigenesis. DJGPhD.7May23 Authentic Biochemistry Podcast
References
Int J Mol Sci. 2020 Jun; 21(11): 4098.
3 years, 5 months ago
ImmunoEpigenetics59. The P53/AKT/PHLDA3 axis over tumorigenicity is controlled by endomembraneous targeting via glycerol lipid PhosphatidylInositol bis-phosphate (PIP2) phosphorylation to PIP3.5.12.23
References
Int J Mol Sci. 2020 Jun; 21(11): 4098.
Authentic Biochemistry lectures :ImmunoEpigenetics 56-58
3 years, 5 months ago
ImmunoEpigenetics 58. Epigenetic mechanisms role in Loss of Heterozygosity (LOH) in TSG's advancing targeting of solid tumors via pharmacotherapeutic CAR-T cells. DJGPhD 27.4.23. Authentic Biochem.
References
BMC Medical Genomics. 2015. volume 8, Article number 45.
Journal for ImmunoTherapy of Cancer 2022;10:e003826.
3 years, 6 months ago
ImmunoEpigenetics 57. Plasmacytoid dendritic cell neoplasias and the CAR-T cell tumor microenvironment exposure altering epigenetic TF regulation leading to diverse differentiation. DJGPhD.20.4.23
References
Current Oncology Reports. 2020. 1534-6269, May 15, Vol. 22, Issue 6.
Cell. 2021 Dec 9; 184(25):6081–6100.e26.
3 years, 6 months ago
ImmunoEpigenetics 56. Dendritic cell immunobiochemistry introductions. DJGPhD. Authentic Biochemistry 15.4.23
References
Autoimmunity. 2012 Aug;45(5):333-47
Clinical and Experimental Rheumatology 2019: One year in review 2019: systemic lupus erythematosus
Tr…
3 years, 6 months ago