Podcast Episodes

Holiday Ethanol Use VI. EtOH associated DNA methylation of neurotransmitter systems opens the door to neurotoxicity and cognitive deficits. DJGPhD.18.12.22b. Authentic Biochemistry Podcast

References

Dr Guerra EtOH lectures

Dr Guerra Reward Pathway lectures

Biol Psychiatry. 2020 Jan 1; 87(1): 64–73

Biochemistry and Cell Biology. 2019. V…

3 years, 5 months ago

Holiday Ethanol Use V. EtOH mediated WNT signaling and PLC mediated IP3/DAG induction of protein kinase and Ca2+ mobilization contribute to aberrant transcription and translation corrupting health.

References

Dr Guerra EtOH lectures

Physiol Rev 2016. 96: 1261–1296.

Clinical and Molecular Teratology. 2016. Volume 106, Issue 9 Pages 749–760

3 years, 5 months ago

Holiday Ethanol Use IV. MDH and LDH play essential roles in EtOH mediated corruption of bioenergetics, development, and gene expression during fetal development.DJGPhD.16.12.22 b.Authentic Biochem.

References

Dr Guerra's EtOH lectures

Cells. 2020 Sep; 9(9): 2125.

3 years, 5 months ago

Holiday Ethanol Use III. In utero fetal cardiac muscle development is corrupted by maternal EtOH exposure via metabolic, bioenergetic and epigenetic means involving fatty acid and folate redox poise.

References

Dr. Guerra's EtOH lectures

Clinical and Molecular Teratology 2016. Volume 106:749–760

Stat Pearls. Embryology and Gastrulation. NIH 2022. …

3 years, 5 months ago

Holiday EtOH Lecture II. Ethanol ingestion permanantly corrupts myelin lipid composition while altering MET and Folate metabolism leading to epigenetic syntactic and semantic chromatin errors.DJGPhD.

References

Clinical and Molecular Teratology Volume 106, Issue 9 September 2016 Pages 749–760

Alcohol, 2017-12-01, Volume 65, Pages 51-62

3 years, 5 months ago

Immunoepigenetics VII. MicroRNA mediated feedback control over signalling response toward inflammation.DJGPhD. 10Dec22. Authentic Biochemistry

References

Arthritis Res Ther. 2021; 23: 19.

Frontiers in Immunology.  November 2014. 21(578):1

3 years, 5 months ago

ImmunoepigeneticsV!. TLR's and TCR's use membrane lipid raft signal transduction to obtain transcription factor mediated cell fate via epigenetic modification. DJGPhD.09 Dec.22

References

Frontiers in Immunology November 2014. 21(578):1

Clin Epigenetics. 2017; 9: 94

 Cancer Cell International September 2020. 20(1):429

3 years, 6 months ago

ImmunoepigeneticsV. TCR activation and the integration of cell senescence with epigenetic authorship and reading-mediated tumorigenesis. DJGPhD.07Dec22. Authentic Biochemistry

References

Cancer Cell Int. 2022; 22: 272.

Cell Mol Life Sci. 2013 Oct;70(20):3753-72

PLoS Biol. 2013 Mar; 11(3): e1001502

3 years, 6 months ago

ImmunoEpigeneticsIV. Membrane lipid raft components dynamically mediate Tcell reception, hippocampal pyrimidal neuron endocytosis, and lung cancer cell mesenchymal to endothelial transition.DJGPhD.

References

Respir Res. 2017 Sep 6;18(1):168

Front Behav Neurosci. 2020; 14: 24

JLR Methods| 2020.Volume 61, ISSUE 11, P1512-1523, November 01

3 years, 6 months ago

Immunoepigenetics 3. EtOH abuse interrupts membrane lipid raft -mediated TCR signaling by decreasing the TF NFAT nuclear translocation and IL-2 transcription.DJGPhD.04.DEC.22.Authentic Biochemistry.

Reference

Alcohol Clin Exp Res. 2011 Aug; 35(8): 1435–1444

3 years, 6 months ago