Podcast Episodes

ImmunoEpigenetics XXXIX. T cell acute lymphoblastic leukaemia genetics and epigenetics: the role of chromatin retailoring via histone LYS acetylation/deacetylation event ontology. DJGPhD.3March23

References

Genes (Basel). 2021 Aug; 12(8): 1118.

Nature Reviews Immunology 2018. volume 18, pages 617–634.

3 years, 4 months ago

ImmunoEpigenetics XXXVIII. Tcell receptor activation and the PIP3/AKT/mTORCI/mTORCII control over cytokine expression:a primer. DJGPhD.2March2023.Authentic Biochemistry Podcast.

References

Guerra's immunology lectures

Experimental & Molecular Medicine volume 51, Article number: 80 (2019)

Genes (Basel). 2021 Aug; 12(8): 1118

3 years, 4 months ago

ImmunoEpigenetics XXXVII. Differential substrates for the Adenylate Cyclase-PKA phosphorylation cascade distributes assymetric inflammatory, hormonal and metabolic sequalae. DJGPhD.01March23.

REferences

Dr Guerra's graduate biochemistry lectures

J Biol Chem. 2013 Mar 8; 288(10): 7137–7146

3 years, 4 months ago

ImmunoEpigeneticsXXXVI. Tumor-specific methylation respondent transcription of Adenylate Cyclase 2 may be linked to differential cytokine expression controlling T cell activation. DJGPhD.01March23.

References

Naunyn Schmiedebergs Arch Pharmacol . 2014 Apr;387(4):329-39.

J Biol Chem. 2013 Mar 8; 288(10): 7137–7146

J Anim Sci. 1998 Jan;76(1):160-7…

3 years, 4 months ago

Immunoepigenetics XXXIV. Methylation signatures in neoplasias1. DJGPhD. Authentic Biochemistry Podcast Productions. 26.2.23

References

Journal of Bone Oncology 2017. Volume 9, November.  Pages 34-40

Journal of Disease and Global Health 15(3): 22-47, 2022.ISSN: 2454-1842, N…

3 years, 4 months ago

ImmunoEpigenetics XXXIII. Crisper CAS , small molecule,and LOXP-CRE targeting of SDH/ComplexII decrease Th1 cytokine production: Standard Oxidation Potentials and TCA anapleurotic involvement.DJGPhD.

References

Nature. 2019 Jul; 571(7765): 403–407

Dr Guerra's lectures

3 years, 4 months ago

ImmunoEpigeneticsXXXII. Apriori synthesis of the glycolytic/TCA/ETC axis mediating target and endogenous apoptotic control with Th and NK cell activation/proliferation and effector function. DJGPhD.

References

 Authentic Biochemistry Podcast  Immunoepigenetics lectures XXIX-XXX1

Dr. Guerra's intermediary metabolism and bioenergetics lectures

Natu…

3 years, 4 months ago

ImmunoEpigenetics XXXI. The role of SDH on Complex II electron flow to ubiquinone subsequent to cardiac arrest is associated neuronal PCD similar to Tcell bioenergetic switching during activation.

References

J of Intensive Care. 2020. volume 8, Article number: 60.

Neuroscience. 2018 Nov 21;393:24-32

Cancers 2020, 12(11), 3237

Nature. 2019 Jul; …

3 years, 4 months ago

Immunoepigenetics XXX.NK lymphoyctes programed tumor cell death by titrating anti-apoptotic BCL proteins with BH3 pro-apoptotic events. DJGPhD. 17.2.23. Authentic Biochemistry Podcast

References

Cancers (Basel). 2020 Aug; 12(8): 2137.

Cell Death Dis. 2020 Jan 2;11(1):5

Cell. 2022. 185. 9. :521-1538.e18

3 years, 5 months ago

ImmunoEpigenetics XXIX. Apoptosis unthwarted:preventing phosphorylation of RNAPOLII tanks histone acetylation near Mcl enhancer region thus epigenetically inhibiting expression in glioblastoma cells.

References

Cell Death & Differentiation 2020.27: 3374–3385 

Cell Death & Differentiation 2019. 26: 1501–1515

Cancers  2020, 12(8), 2137.

3 years, 5 months ago