Podcast Episodes

Holiday Ethanol Abuse Lecture I. EtoH ingestion, while intoxicating redox metabolism is also a membrane lipid -protein interacting agent that corrupts inwardly rectifying K voltage gated channels.

References

Dr Guerra EtOH lectures

PNAS November 5, 2013 vol. 110 no. 45

Alcohol, 2017-12-01, Volume 65, Pages 51-62

3 years, 4 months ago

ImmunoEpigeneticsIX. Promoter/Enhancer proximal and distal epigenetic signatures and transcription factor protein heterogeneity compose gene expression event ontology.DJGPhD.29.12.22.AuthenticBiochem

References

Proc Natl Acad Sci U S A. 2021 Nov 16; 118(46)

Nat Rev Mol Cell Biol. 2021 Dec 1; 22(12): 815–833. 

3 years, 4 months ago

More "mere" epistemology opening a door to metaphysics II. Non-canonical epi-rational and epi-empirical retailoring of understanding and imagination via research scientific endojectification.DJGPhD.

References

Dr. Guerra's ongoing flight into the telos of research science.

3 years, 5 months ago

ImmunoepigeneticsVIII. Protective immunotolerant neonate Th1 inactivity involves IL-12 p35subunit promoter methylation. DJGPhD.23.12.22. Authentic Biochemistry Podcast

References

Trends in Immunology. REVIEW. 2017. VOLUME 38, ISSUE 4, P287-297.

J Biomed Sci. 2014 Aug 19;21(1):76.

3 years, 5 months ago

Holiday Ethanol Use VIII. EtOH induced cAMP /CREB associated PKA kinase driven phosphorylation cascade co-opts the TLR4-mediated neuroinflammatory/neurotoxic CNS-microglial axis.DJGPhD.22.12.22.AB.

References

Neural Plasticity. 2019; 2019: 1648736.

Molecular Pharmacology May 2017, 91 (5) 451-463.

3 years, 5 months ago

Holiday Ethanol Use VII. EtOH exposure precipitates chromatin methylation associated MCH and chemokine involvement linking arousal, reward and inflammation. DJGPhD.21.12.22 Authentic Biochem.

References

PLoS One. 2011;6(5):e17711

J Neuroinflammation. 2020; 17: 207

Front Neurosci. 2019 Nov 26;13:1280

3 years, 5 months ago

Mere Epistemology Knocking on Metaphysics for a late December Evening. I. DJGPhD.21 December 2022 Authentic Biochemistry Podcast

References

Dr Guerra's ideas and concepts concerning the epistemics of research science . Lecture I.

3 years, 5 months ago

Holiday Ethanol Use VI. EtOH associated DNA methylation of neurotransmitter systems opens the door to neurotoxicity and cognitive deficits. DJGPhD.18.12.22b. Authentic Biochemistry Podcast

References

Dr Guerra EtOH lectures

Dr Guerra Reward Pathway lectures

Biol Psychiatry. 2020 Jan 1; 87(1): 64–73

Biochemistry and Cell Biology. 2019. V…

3 years, 5 months ago

Holiday Ethanol Use V. EtOH mediated WNT signaling and PLC mediated IP3/DAG induction of protein kinase and Ca2+ mobilization contribute to aberrant transcription and translation corrupting health.

References

Dr Guerra EtOH lectures

Physiol Rev 2016. 96: 1261–1296.

Clinical and Molecular Teratology. 2016. Volume 106, Issue 9 Pages 749–760

3 years, 5 months ago

Holiday Ethanol Use IV. MDH and LDH play essential roles in EtOH mediated corruption of bioenergetics, development, and gene expression during fetal development.DJGPhD.16.12.22 b.Authentic Biochem.

References

Dr Guerra's EtOH lectures

Cells. 2020 Sep; 9(9): 2125.

3 years, 5 months ago