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ImmunoEpigenetics49.SiRNA knockdown of ME1 increases Haeme Oxygenase activity in both glucose supplemented and deprived cancer cells. The Pseudoparadox of epigenetic control over metabolism. DJGPhD
References
Dr Guerra's lectures and spontaneous expectorations.
Molecular Cancer 2020. volume 19, Article number: 39
3 years, 3 months ago
ImmunoEpigenetics48. Importance of malic enzyme isoform subcellular distribution using 13CNMR -U13C C6 glucose isotopomer detection of pathway intermediates:GSIS vs. cancer.DJGPhD.21.3.23
References
Methods Enzymol. 2009; 457: 425–450
Endocrinology, Volume 155, Issue 5, 1 May 2014, Pages 1653–1666
Am J Physiol Endocrinol Metab. 2008 De…
3 years, 3 months ago
Immunoepigenetics 47. Intermediary metabolism re-enters the discussion on tumor corruption of cell division via diversion of glucose to NADPH production.DJGPhD
References
Dr Guerra's lectures
AJP Endocrinology and Metabolism. 2008. 295(6):E1287-97
Biochem Biophys Res Commun.1996 May 15;222(2):287-91
Carc…
3 years, 3 months ago
ImmunoEpigenetics 46.The Keap1/Nrf2/MAF axis in colorectal cancer: Methylation specific promoter mediated expression of anti-oxidant genes unveiling a complex role in tumorigenesis.DJGPhD.15.3.23
References
Carcinogenesis. 2020 Jun; 41(4): 405–416
Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39
3 years, 4 months ago
ImmunoEpigenetics 45. Innate immune cell nSMASE generates ceramide mediated TLR signalling epigenetic alterations resulting in COX-2 electrophile PG- Michael adduct removal of KEAP/Nrf2 association.
References
Carcinogenesis. 2020 Jun; 41(4): 405–416
Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39
3 years, 4 months ago
ImmunoEpigenetics 44. Ceramide and NRF2 mediate oxygen stress and the pro-inflammatory cytokine respose via association with chromatin epigenetic retailoring. DJGPhD.8March23. Authentic Biochemistry.
References
Antioxidants (Basel). 2023 Feb; 12(2): 274
J Lipid Res. 2016 May; 57(5): 868–881.
J Biol Chem. 2007 Jan 12;282(2):1384-96.
J. Am. Chem. So…
3 years, 4 months ago
ImmunoEpigenetics XXXXIII. In silico analysis of Rheumatoid Arthritis methylation patterns fails to obtain a general rule for epigenetic regulation of gene expression.DJGPhD07March23. ABPe
References
Int J Hematol 2022. 116, 828–836
Cancer Immunol Res (2022) 10 (1): 87–107
Front Immunol. 2022; 13: 881191
Nature Reviews Immunology 2018. …
3 years, 4 months ago
ImmunoEpigenetics XXXXII. T-ALL Homeobox A gene alteration of MEF2C expressional variation linked to T-cell differentiation blockade as regulated by CaMK and HDAC4/HDAC5. DJGPhD. 05March23.
References
Biochem J 2012 444(1):105-114
Epigenetics. 2015 May; 10(5): 418–430.
Nature Reviews Immunology volume 2018. 18, pages 617–634
3 years, 4 months ago
ImmunoEpigenetics XXXXI. From Programmed Cell Death to Homeobox gene clusters, T-ALL leukaemias involve epigenetic events. DJGPhD.05March23. Authentic Biochemistry Podcast
References
Genes & Diseases Available online 26 December 2022
Int J Mol Sci. 2021 May; 22(10): 5317
Haematologia 2016. Vol. 101 No. 6 June.
Blood (2…
3 years, 4 months ago
ImmunoEpigenetics XXXX. Transcription factor complex permutaions combine with histone acetylomic and methylomic covalent mofications in T -ALL disease. DJGPhD. 04 March 2023. Authentic Biochemistry.
References
Nature Reviews Immunology volume 18, pages 617–634 (2018)
Genes (Basel). 2021 Aug; 12(8): 1118.
3 years, 4 months ago