Podcast Episodes

BioMedical Portrait III.c12. Senescent cells from aging and obesity obtain chronic hyperinflammation of adipose associated leucocyte infiltrates potentiating alternating systemic proliferation or PCD.

References

Haydn, Michael. 1760. Salve Regina in G MH32. https://youtu.be/u_Xjo5KJ3mg?si=kmKaaBJMvUgs_blX

Leukemia 2020. volume 34, pages 75–86

CELL…

3 years, 1 month ago

BioMedical Portrait III. AMPK regulation of ACC2 blocks MalCoA inhibition of CPTI allowing for fatty acid beta oxidation thus alleviating adipose obesity-induced macrophage pro-inflammation.DJGPhD.

References

Saint-Saens. C. 1886. Symphony 3 (avec orgue) OP.78

J Clin Invest. 2011 Dec 1; 121(12):4903–4915

Cell Metab. 2022 Dec 6; 34(12): 2036–2046…

3 years, 1 month ago

BioMedical Portrait III. c10. Ribosomal collision frequency is attenuated by ZAK and GCN2 via mutually exclusive signalling events, DJGPhD. 25.9.23. Authentic Biochemistry Podcast

References

Cell. 2020 Jul 23; 182(2):404–416.e14.

Curr Genet. 2021 Feb; 67(1): 19–26.

RNA Biol. 2023; 20(1): 737–749. published online 13sept23

3 years, 1 month ago

BioMedical Portrait III. c9. Amino acid deprivation-linked fall of polypeptide synthetic fidelity triggers downstream ribosomal stress response phenomena including kinase mediated cell fate sequalae.

References

Cell. 2020 Jul 23; 182(2):404–416.e14.

Nature Communications 2020. volume 11,3146

Curr Genet. 2021 Feb; 67(1):19–26

3 years, 1 month ago

BioMedical Portrait III. c8. Unique mRNA upstream open reading frames direct both the integrated stress response and rare selective up-regulation of stress-correcting protein synthesis.DJGPhD.21.9.23

References

Dr Guerra's lectures

RNA Biol. 2023; 20(1): 737–749

3 years, 1 month ago

BioMedical Portrait III.c.7 Elementary polypeptide synthesis-translation. Lecture 1. DJGPhD.20.9.23.Authentic Biochemistry Podcast.

Reference

Dr Guerra's lecture notes

3 years, 1 month ago

BioMedical Portrait III. c6. Adipokine and the succinate receptor systems in obese adipose inflammation as regulated by AMPK.DJGPhD.19.9.23. Authentic Biochemistry Podcast

References

Cream 1968 Wheels of Fire

J Neuroinflammation. 2019; 16: 34.

Front Immunol. 2019; 10: 345.

Cell Metabolism 2023. Volume 35 Issue 4. 601-6…

3 years, 1 month ago

BioMedical Portrait III.c.5. Adipokine mediated adipose inflamation is linked to the hypothalamic control over metabolism and systemic inflammation.DJGPhD.18.9.23.Authentic Biochemistry Podcast

References

Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55

Int J Biol Sci. 2015; 11(11):1272–1280

Front. Physiol., 01 June 2018

Int. J. …

3 years, 1 month ago

BioMedical Portrait III. c.4. Adipose tissue macrophages express galectin binding proteins which alter immunosuppression and polarization;adipokines mediate the inflammatory response. DJGPhD.17.9.23

References

Luigi Boccherini: Symphony Op. 12 No. 4 in D Minor

JCI Insight. 2016 Nov 17; 1(19): e87748

Front Immunol. 2023; 14: 1149366

Adv Biol Regu…

3 years, 1 month ago

BioMedical Portrait III. Immunometabolic disease 3c.Reactive N and O interconversions in obese adipose exacerbate systemic inflammation. 17.9.23. DJGPhD. Authentic Biochemistry Podcast.

References

Inn Med (Heidelb). 2023 Apr;64(4):313-322.

JBC 2001. Volume 276, Issue 31, August. Pages 28799-28805.

3 years, 1 month ago