Podcast Episodes

ImmunoEpigenetics 46.The Keap1/Nrf2/MAF axis in colorectal cancer: Methylation specific promoter mediated expression of anti-oxidant genes unveiling a complex role in tumorigenesis.DJGPhD.15.3.23

References

Carcinogenesis. 2020 Jun; 41(4): 405–416

Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39

3 years, 2 months ago

ImmunoEpigenetics 45. Innate immune cell nSMASE generates ceramide mediated TLR signalling epigenetic alterations resulting in COX-2 electrophile PG- Michael adduct removal of KEAP/Nrf2 association.

References

Carcinogenesis. 2020 Jun; 41(4): 405–416

Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39

3 years, 2 months ago

ImmunoEpigenetics 44. Ceramide and NRF2 mediate oxygen stress and the pro-inflammatory cytokine respose via association with chromatin epigenetic retailoring. DJGPhD.8March23. Authentic Biochemistry.

References

Antioxidants (Basel). 2023 Feb; 12(2): 274

J Lipid Res. 2016 May; 57(5): 868–881.

J Biol Chem. 2007 Jan 12;282(2):1384-96.

J. Am. Chem. So…

3 years, 2 months ago

ImmunoEpigenetics XXXXIII. In silico analysis of Rheumatoid Arthritis methylation patterns fails to obtain a general rule for epigenetic regulation of gene expression.DJGPhD07March23. ABPe

References

Int J Hematol 2022. 116, 828–836

Cancer Immunol Res (2022) 10 (1): 87–107

Front Immunol. 2022; 13: 881191

Nature Reviews Immunology 2018. …

3 years, 2 months ago

ImmunoEpigenetics XXXXII. T-ALL Homeobox A gene alteration of MEF2C expressional variation linked to T-cell differentiation blockade as regulated by CaMK and HDAC4/HDAC5. DJGPhD. 05March23.

References

Biochem J 2012 444(1):105-114

Epigenetics. 2015 May; 10(5): 418–430.

Nature Reviews Immunology volume 2018. 18, pages 617–634 

3 years, 2 months ago

ImmunoEpigenetics XXXXI. From Programmed Cell Death to Homeobox gene clusters, T-ALL leukaemias involve epigenetic events. DJGPhD.05March23. Authentic Biochemistry Podcast

References

Genes & Diseases Available online 26 December 2022

Int J Mol Sci. 2021 May; 22(10): 5317

Haematologia 2016. Vol. 101 No. 6  June.

Blood (2…

3 years, 2 months ago

ImmunoEpigenetics XXXX. Transcription factor complex permutaions combine with histone acetylomic and methylomic covalent mofications in T -ALL disease. DJGPhD. 04 March 2023. Authentic Biochemistry.

References

Nature Reviews Immunology volume 18, pages 617–634 (2018)

Genes (Basel). 2021 Aug; 12(8): 1118.

3 years, 2 months ago

ImmunoEpigenetics XXXIX. T cell acute lymphoblastic leukaemia genetics and epigenetics: the role of chromatin retailoring via histone LYS acetylation/deacetylation event ontology. DJGPhD.3March23

References

Genes (Basel). 2021 Aug; 12(8): 1118.

Nature Reviews Immunology 2018. volume 18, pages 617–634.

3 years, 2 months ago

ImmunoEpigenetics XXXVIII. Tcell receptor activation and the PIP3/AKT/mTORCI/mTORCII control over cytokine expression:a primer. DJGPhD.2March2023.Authentic Biochemistry Podcast.

References

Guerra's immunology lectures

Experimental & Molecular Medicine volume 51, Article number: 80 (2019)

Genes (Basel). 2021 Aug; 12(8): 1118

3 years, 2 months ago

ImmunoEpigenetics XXXVII. Differential substrates for the Adenylate Cyclase-PKA phosphorylation cascade distributes assymetric inflammatory, hormonal and metabolic sequalae. DJGPhD.01March23.

REferences

Dr Guerra's graduate biochemistry lectures

J Biol Chem. 2013 Mar 8; 288(10): 7137–7146

3 years, 2 months ago