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BioMedical Portrait IV c8. Proteolytic processing of cytosolic RNA-bp ,TDP43, associates with CNS neuropathologies while native nuclear translocation is linked to exon shuffling. DJGPhD.12Oct23.
References
Molecular Neurobiology 2022. volume 59, pages 4223–4241
Hum Genet. 1994 Jan;93(1):67-73
Mol Cell Biol. 2012 Jan;32(1):126-38
3 years ago
BioMedical Portrait IV c7.Progranulin associated frontotemporal lobar degeneration and AD, PD, and LBD, share a TDP-43 proteinopathy linked to mRNA translation. DJGPhD.11OCT23. Authentic Biochemistry
References
The EMBO Journal (2022)41:e109108
Acta Neuropathol. 2007 Sep;114(3):221-9
Acta Neuropathol.2013 Jul; 126(1): 51–57
Brain 2008. Volume 131,…
3 years ago
BioMedical Portrait IV. c6. Proteinopathies in neurodegeneration may be the result of insufficient temporal control over microglial phagocytic and pro-inflammatory molecular event ontologies.DJGPhD
References
Brooker, G; Fisher, M and Reid, K. Procol Harum 1967. A Whiter Shade of Pale. https://music.youtube.com/watch?v=z0vCwGUZe1I&si=4iY2IY06x74…
3 years ago
BioMedical Portrait IV.c5. Microglial removal of lipoprotein and proteinopathic molecular events must include lysosomal degradation and antigen presentation while supporting signaling and inflammation
References
Mozart, WA. 1791. Clarinet Concerto in A major, K. 622 https://youtu.be/YT_63UntRJE?si=bXBDcxTxsY1PxJa5
Small GTPases. 2014; 5: e28579
…3 years ago
BioMedical PortraitIVc4. Microglial Rho GTPases equipped with GGylation, palmitoylation and/or phosphorylation obtain a spectrum of biochemical functions in neuropathologies.DJGPhD.8Oct23b. Authentic.
References
Mol Biol Cell. 2001 Sep; 12(9): 2711–2720.
Small GTPases. 2014; 5: e28579.
Cells. 2021 Jul 20;10(7):1831.
J Investig Med. 2023 Feb;71(2…
3 years ago
BioMedical Portrait IV. c3. Two down-regulated microglial polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy distinct LDL binding proteins typically cargo oxy cholesterol.
References
Sinatra, Frank. timeless. My Way. https://youtu.be/qQzdAsjWGPg?si=TcpVOHDikKyyQdmC
Acta Neuropathol. 2023 Jun;145(6):749-772
Signal Transd…
3 years ago
BioMedical PortraitIV.NHD patient fibroblasts used to generate iPSC's differentiated into Induced microglia like cells (iMGLs) pathophenocopied TREM2 mutations and lysosomal malfunctions.DJGPhD.
References
Neurol Genet. 2018 Jan 18;4(1):e211.
J Immunol (2003) 171 (2): 594–599.
Acta Neuropathol. 2023; 145(6): 749–772.
3 years ago
BioMedical Portrait IV. HLA disease including neuropatholgies. The Nasu-Hakola, a.k.a. polycystic lipomembranous osteodysplasia associated TREM2 disease. DJGPhD.04Oct2023.Authentic Biochemistry.
References
Neurology. 2020 Jul 7; 95(1): e46–e58
Acta Neuropathol. 2023; 145(6): 749–772.
3 years ago
BioMedical PortraitIIIC13c. Leucocyte and lymphocyte mediated SASP involve a corruption in robust novel immune responses while enhancing chronic autoimmune inflammation in the obese and elderly.DJGPhD
References
Curr Opin Pharmacol. 2021 Apr; 57: 107–116
3 years ago
BioMedical PortraitIII. c13b.Immune cell metabolic dialectical usurpation of architechtonic control over inflammation and cell fate obtained from senescence and obesity.-linked dyslipidaemia.DJGPhD.
References
Pisendel Johann G. 1735. Violin Concerto in D major Jun P I.7 https://youtu.be/dvwhXXvFiNg?si=BUb-f5rBncgADinx
Curr Opin Pharmaco…
3 years, 1 month ago