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Biochemical Mosaic I. Phosphatidic acid Phosphatase. c.7. Mutational reversal of IDH1 leads to NADPH depletion concomitant with potent anti-PHD enantiomeric 2-hydroxyglutarate obtaining pseudohypoxia.
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Discoveries(Craiova). 2017 Jul-Sep; 5(3): e77.
J Cell Mol Med. 2015 Jul; 19(7): 1427–1440.
Onc…
2 years, 5 months ago
Biochemical Mosaic I. The PA phosphatase c.6. Alteration of the TCA pathway intermediates and hypoxia/nutrient deficiency control HIF1α stability indirectly regulating IMM protein and lipid turnover.
References
Front. Oncol. 2017. 26 November.V.7.
Oncogene. 2017 Mar 23; 36(12): 1607–1618.
Schubert, F. 1819 Piano Quintet in A major, D. 667/ "Trout…
2 years, 5 months ago
The Biochemical Mosaic I. Phosphatidic Acid Phosphatase c.5. Tumor cells adapt bioenergetic fuel economy toward cell immortalization via re-crafting of mitochondrial IM lipid speciation.DJGPhD.12Feb24
References
Cell Metabolism 2019. 30: 720–734
Nature 2019. 575: 361–365
Squire, C. 1978. "Onward" Yes.
2 years, 5 months ago
Biochemical Mosaic I. Phosphatidic Acid Phosphatase c.4 GLN utilization and an IMM protease regulate mitochondrial involvement in cancer growth. DJGPhD. Authentic Biochemistry 10Feb24
References
Cell Death & Disease 2022. volume 13.Article number: 444.
Nature 2019. volume 575, pages 361–365
Scientific Reports 2021. volume 11, Arti…
2 years, 5 months ago
Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. c.3 Indirect consequences of mitochondrial proteomic variation potentially obtains GLN-linked Warburg glycolysis preventing ROS.
References
Cell Metabolism 2019. 30, 720–734
Redox Biology2013. Volume 1, Issue 1: 427-432
Nature 2019. volume 575. 361–365 Mozart, WA, 1779.Sinfonia…
2 years, 5 months ago
Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. Autophagy commitment is linked to mTORC1 v. AMPK oppostional kinase networks maintaining proteostasis and lipid homeostasis.DJGPhD
References
Nature 2019.volume 575, pages 361–365
Cells 2022, 11(21), 3339
Guerra: Polypeptide, endomembranous lipid homeostasis, and bi…
2 years, 5 months ago
Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. Prologomena c.1.
References
J Cell Biol. 2014 Mar 17; 204(6):919–929
Nature 2019. Volume 575, pages 361–365.
Redox Biology 2013. Volume 1, Issue 1. Pages 427-432.
Mad…
2 years, 5 months ago
BioMedical Portrait VIII. C.22 CODA. Microglial Leukotrienes in neurodegeneration.DJGPhD.04Feb2024. Authentic Biochemistry Podcast.
References
Acta Neuropathologica Communications 2020. volume 8, Article number: 129.
J Lipid Res. 2019 Feb; 60(2): 219–226.
Palestrina, G. 1562. Mis…
2 years, 5 months ago
BioMedical Portrait VIII. c.21 Lysopholpids like sphingolipids hydrogen bond to cholesterol mediating lipid membrane raft mobility. DJGPhD. 2Feb2024. Authentic Biochemistry Podcast
References
Biochimica et Biophysica Acta (BBA) - Biomembranes2015. Volume 1848, Issue 3, Pages 805-812
Soft Matter 21-Jan-2021
Am J Rhinol Allergy. 2…
2 years, 5 months ago
BioMedical Portrait VIII C.20. Heterologous lipid sequence membrane domains rearrange according to LysoPL polarity after PLA2 mediated 20:4 removal and acetosalicylic acid alters fatty acid ordering.
References
Soft Matter, 2021,17, 2742-2752
BBA Biomembranes 2015 Volume 1848, Issue 3, Pages 805-812
Mozart, WA. 1788. Divertimento in E Major.K 563.…
2 years, 5 months ago