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Biochemical Mosaic I. c.12. The porosomal secretory system requires anioic lipids including phosphatidic acid. DJGPhD.21.2.24
Dr. Guerra: membrane graduate biochemistry lecture notes
J Cell Mol Med . 2015 Jul;19(7):1427-40
Langmuir, 2018, 34 (1), pp 530–539
Elgar, E. 1900. T…
2 years, 3 months ago
Biochemical Mosaic I.c.11. Glycerolipid metabolism coupled to mTORC1 enzyme phosphorylation necessarily involves a complete analysis of membrane lipid molecular species distribution.DJGPhD.20.2.24
References
Nature . 2019 Nov;575(7782):361-365.
Adv Biol Regul. 2017 May:64:39-48
J Biol Chem. 2013 Apr 5; 288(14): 9933–9945
Redox Biology.2017. V…
2 years, 3 months ago
Biochemical Mosaic I c.10. Is PE depletion reversed by mTORC1 phosphorylation of LIPIN1 or is DAG authentically activating CCT via membrane association thus obtaining robust PL synthesis? DJGPhD.
References
Biochim Biophys Acta. 2011 Jun;1811(6):377-85
Am J Physiol Lung Cell Mol Physiol 2001. 281: L98–L107.
Biochimica et Biophysica Acta…
2 years, 3 months ago
Biochemical Mosaic I. c.9 Increased inner mitochondrial membrane PE from PS decarboxylase decreases protease mediated degradation of phospholipid transfer proteins thus maintaining fusion potency.
References
PLoS Biol 2014. 12(10): e1001969
J Biol Chem. 2012 May18;287(21):17589-17597
J Biol Chem. 2012 Nov 23;287(48):40131-9
Nature 2019. volume …
2 years, 3 months ago
Biochemical Mosaic I PA-phosphatase c.8. Membrane fusion and the dynamics of mitochondrial reduction vs. proliferation; the PA phosphatase in lipid metabolism. DJGPhD. 16.2.24 Authentic Biochemistry
References
Dr Guerra membrane lectures archive
FASEB J. 2021 Jun; 35(6): e21620.
Vivaldi, A. 1711. Concerto for 4 Violins in B minor RV 580
https://…
2 years, 3 months ago
Biochemical Mosaic I. Phosphatidic acid Phosphatase. c.7. Mutational reversal of IDH1 leads to NADPH depletion concomitant with potent anti-PHD enantiomeric 2-hydroxyglutarate obtaining pseudohypoxia.
References FEMS Microbiol Rev.1998. Oct;22(4):255-75
Discoveries(Craiova). 2017 Jul-Sep; 5(3): e77.
J Cell Mol Med. 2015 Jul; 19(7): 1427–1440.
Onc…
2 years, 3 months ago
Biochemical Mosaic I. The PA phosphatase c.6. Alteration of the TCA pathway intermediates and hypoxia/nutrient deficiency control HIF1α stability indirectly regulating IMM protein and lipid turnover.
References
Front. Oncol. 2017. 26 November.V.7.
Oncogene. 2017 Mar 23; 36(12): 1607–1618.
Schubert, F. 1819 Piano Quintet in A major, D. 667/ "Trout…
2 years, 3 months ago
The Biochemical Mosaic I. Phosphatidic Acid Phosphatase c.5. Tumor cells adapt bioenergetic fuel economy toward cell immortalization via re-crafting of mitochondrial IM lipid speciation.DJGPhD.12Feb24
References
Cell Metabolism 2019. 30: 720–734
Nature 2019. 575: 361–365
Squire, C. 1978. "Onward" Yes.
2 years, 3 months ago
Biochemical Mosaic I. Phosphatidic Acid Phosphatase c.4 GLN utilization and an IMM protease regulate mitochondrial involvement in cancer growth. DJGPhD. Authentic Biochemistry 10Feb24
References
Cell Death & Disease 2022. volume 13.Article number: 444.
Nature 2019. volume 575, pages 361–365
Scientific Reports 2021. volume 11, Arti…
2 years, 3 months ago
Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. c.3 Indirect consequences of mitochondrial proteomic variation potentially obtains GLN-linked Warburg glycolysis preventing ROS.
References
Cell Metabolism 2019. 30, 720–734
Redox Biology2013. Volume 1, Issue 1: 427-432
Nature 2019. volume 575. 361–365 Mozart, WA, 1779.Sinfonia…
2 years, 3 months ago