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Biochemical Mosaic III.c.10 Atherogenesis and neointma formation are associated with sphingomyelinase membrane raft NOX aggregation during inflammasome activation.DJGPhD.2April24
References
J Lipid Res. 2022 Dec; 63(12): 100298.
Mol Cells. 2020 Aug 31; 43(8): 749–762.
Bach J.S. 1727. St Matthew Passion, BWV 244.
https://www.…
2 years, 3 months ago
Biochemical Mosaic III.c.9 Clinical associations of inflammasome mediated pathophysiology linked to epigenetic methylation patterning and DNA repair. DJGPhD.1April24.
References
Redox Biol. 2020 Apr; 31: 101482
Nat Rev Microbiol. 2009 Feb; 7(2): 99–109.
J Neuroinflammation. 2019; 16: 236.
Front Pharmacol. 2021; 12…
2 years, 3 months ago
Biochemical Mosaic III.c.8. S. aureus clearance via dual pyroptosis and necroptosis salientsand the control over the hyperinflammatory axis of clinical disease. DJGPhD.31.3.24
References
Cell Reports 2016.Volume 16, Issue 8, 23 Pages 2219-2230
Front Immunol. 2020; 11: 621733
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961…
2 years, 3 months ago
Biochemical Mosaic III.c.7 Convergence of Inflammasome molecular patterning obtains PRR-like sequalae that are hypo-modified epigenetically in multple Human pathophysiologies
References
Int J Mol Sci. 2021 Jul; 22(14): 7580.
Trends Biochem Sci. 2023 Apr;48(4):331-344
Immunology. 2020;159:142–155
Curr. Opin. Immunol. 2020;…
2 years, 3 months ago
Biochemical Mosaic III. c.6. S auereus induced inflammasome activating pyroptosis circumvents immune clearance and ARDS pulmonary chronic activation share similar hyperinflammatory presentation.DJGPhD
References
Front Immunol. 2019; 10: 1309
Immunity. 2018 Sep 18; 49(3):413–426.e5.
Front Immunol. 2020; 11: 621733
Infect Immun. 2013 Dec; 81(12): 44…
2 years, 3 months ago
Biochemical Mosaic III. c.5. Gal3 and NRLP3 inflammasome coordinate inflammation via IL-1Beta convertase activation that is associated with NAFLD and NASH and inhibition of ABCA1 cholesterol efflux.
References
Infect Immun. 2013 Dec; 81(12): 4478–4489
Cell Cycle. 2022; 21(11): 1121–1139.
The Journal of Nutritional Biochem.2023.Volume 112, 109217…
2 years, 3 months ago
Biochemical MosaicIII. C.4. My oppositional dialectic and episteme- metaphysical discourse on method+ Gal3 as proinflammatory lectin may not uniformly correlate with pathobiochemical events. DJGPhD.
References
Guerra, DJ. 2024. Uncollected writings.
The Journal of Nutritional Biochemistry 2023. Volume 112, February. 109217
Walker, Cindy.1950 Blue…
2 years, 4 months ago
Biochemical Mosaic III c.3. Bacterial glycosphingolipid mediated inflammasome activation and the Galectin:NLRP3 interaction pathophenocopy oxy-mtDNA TLR induction.DJGPhD.21.3.24
References
Front Immunol. 2020; 11: 591803
Am J Gastroenterol. 2004 Nov;99(11):2147-9.
Biochem Biophys Res Commun. 2005 Dec 16;338(2):1031-6
Front Im…
2 years, 4 months ago
Biochemical Mosaic III. C.2 A Non-canonical autophagic inhibition of NLRP3 inflammasome mediated inflammation in UVB-treated human keratinocytes.DJGPhD. 20.3.24.
References
Front Immunol. 2019 Jun 7;10:1309.
JBC 2024 . March.Article in Press
DOI:https://doi.org/10.1016/j.jbc.2024.107173
FASEB J. 2016 Dec;30(12…
2 years, 4 months ago
Biochemical Mosaic III. C.1. Inflammasomes. DJGPhD.19.3.24 Authentic Biochemistry Podcast
References
Immunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8
JBC 2024. March. Article in Press
https://doi.org/10.1016/j.jbc.2024.107173
Schmelze…
2 years, 4 months ago