Podcast Episodes

Holiday Ethanol Use VIII. EtOH induced cAMP /CREB associated PKA kinase driven phosphorylation cascade co-opts the TLR4-mediated neuroinflammatory/neurotoxic CNS-microglial axis.DJGPhD.22.12.22.AB.

References

Neural Plasticity. 2019; 2019: 1648736.

Molecular Pharmacology May 2017, 91 (5) 451-463.

3 years, 10 months ago

Holiday Ethanol Use VII. EtOH exposure precipitates chromatin methylation associated MCH and chemokine involvement linking arousal, reward and inflammation. DJGPhD.21.12.22 Authentic Biochem.

References

PLoS One. 2011;6(5):e17711

J Neuroinflammation. 2020; 17: 207

Front Neurosci. 2019 Nov 26;13:1280

3 years, 10 months ago

Mere Epistemology Knocking on Metaphysics for a late December Evening. I. DJGPhD.21 December 2022 Authentic Biochemistry Podcast

References

Dr Guerra's ideas and concepts concerning the epistemics of research science . Lecture I.

3 years, 10 months ago

Holiday Ethanol Use VI. EtOH associated DNA methylation of neurotransmitter systems opens the door to neurotoxicity and cognitive deficits. DJGPhD.18.12.22b. Authentic Biochemistry Podcast

References

Dr Guerra EtOH lectures

Dr Guerra Reward Pathway lectures

Biol Psychiatry. 2020 Jan 1; 87(1): 64–73

Biochemistry and Cell Biology. 2019. V…

3 years, 10 months ago

Holiday Ethanol Use V. EtOH mediated WNT signaling and PLC mediated IP3/DAG induction of protein kinase and Ca2+ mobilization contribute to aberrant transcription and translation corrupting health.

References

Dr Guerra EtOH lectures

Physiol Rev 2016. 96: 1261–1296.

Clinical and Molecular Teratology. 2016. Volume 106, Issue 9 Pages 749–760

3 years, 10 months ago

Holiday Ethanol Use IV. MDH and LDH play essential roles in EtOH mediated corruption of bioenergetics, development, and gene expression during fetal development.DJGPhD.16.12.22 b.Authentic Biochem.

References

Dr Guerra's EtOH lectures

Cells. 2020 Sep; 9(9): 2125.

3 years, 10 months ago

Holiday Ethanol Use III. In utero fetal cardiac muscle development is corrupted by maternal EtOH exposure via metabolic, bioenergetic and epigenetic means involving fatty acid and folate redox poise.

References

Dr. Guerra's EtOH lectures

Clinical and Molecular Teratology 2016. Volume 106:749–760

Stat Pearls. Embryology and Gastrulation. NIH 2022. …

3 years, 10 months ago

Holiday EtOH Lecture II. Ethanol ingestion permanantly corrupts myelin lipid composition while altering MET and Folate metabolism leading to epigenetic syntactic and semantic chromatin errors.DJGPhD.

References

Clinical and Molecular Teratology Volume 106, Issue 9 September 2016 Pages 749–760

Alcohol, 2017-12-01, Volume 65, Pages 51-62

3 years, 10 months ago

Immunoepigenetics VII. MicroRNA mediated feedback control over signalling response toward inflammation.DJGPhD. 10Dec22. Authentic Biochemistry

References

Arthritis Res Ther. 2021; 23: 19.

Frontiers in Immunology.  November 2014. 21(578):1

3 years, 10 months ago

ImmunoepigeneticsV!. TLR's and TCR's use membrane lipid raft signal transduction to obtain transcription factor mediated cell fate via epigenetic modification. DJGPhD.09 Dec.22

References

Frontiers in Immunology November 2014. 21(578):1

Clin Epigenetics. 2017; 9: 94

 Cancer Cell International September 2020. 20(1):429

3 years, 10 months ago