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BioMedical Portrait IV.c5. Microglial removal of lipoprotein and proteinopathic molecular events must include lysosomal degradation and antigen presentation while supporting signaling and inflammation
References
Mozart, WA. 1791. Clarinet Concerto in A major, K. 622 https://youtu.be/YT_63UntRJE?si=bXBDcxTxsY1PxJa5
Small GTPases. 2014; 5: e28579
…2 years, 7 months ago
BioMedical PortraitIVc4. Microglial Rho GTPases equipped with GGylation, palmitoylation and/or phosphorylation obtain a spectrum of biochemical functions in neuropathologies.DJGPhD.8Oct23b. Authentic.
References
Mol Biol Cell. 2001 Sep; 12(9): 2711–2720.
Small GTPases. 2014; 5: e28579.
Cells. 2021 Jul 20;10(7):1831.
J Investig Med. 2023 Feb;71(2…
2 years, 7 months ago
BioMedical Portrait IV. c3. Two down-regulated microglial polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy distinct LDL binding proteins typically cargo oxy cholesterol.
References
Sinatra, Frank. timeless. My Way. https://youtu.be/qQzdAsjWGPg?si=TcpVOHDikKyyQdmC
Acta Neuropathol. 2023 Jun;145(6):749-772
Signal Transd…
2 years, 7 months ago
BioMedical PortraitIV.NHD patient fibroblasts used to generate iPSC's differentiated into Induced microglia like cells (iMGLs) pathophenocopied TREM2 mutations and lysosomal malfunctions.DJGPhD.
References
Neurol Genet. 2018 Jan 18;4(1):e211.
J Immunol (2003) 171 (2): 594–599.
Acta Neuropathol. 2023; 145(6): 749–772.
2 years, 7 months ago
BioMedical Portrait IV. HLA disease including neuropatholgies. The Nasu-Hakola, a.k.a. polycystic lipomembranous osteodysplasia associated TREM2 disease. DJGPhD.04Oct2023.Authentic Biochemistry.
References
Neurology. 2020 Jul 7; 95(1): e46–e58
Acta Neuropathol. 2023; 145(6): 749–772.
2 years, 7 months ago
BioMedical PortraitIIIC13c. Leucocyte and lymphocyte mediated SASP involve a corruption in robust novel immune responses while enhancing chronic autoimmune inflammation in the obese and elderly.DJGPhD
References
Curr Opin Pharmacol. 2021 Apr; 57: 107–116
2 years, 7 months ago
BioMedical PortraitIII. c13b.Immune cell metabolic dialectical usurpation of architechtonic control over inflammation and cell fate obtained from senescence and obesity.-linked dyslipidaemia.DJGPhD.
References
Pisendel Johann G. 1735. Violin Concerto in D major Jun P I.7 https://youtu.be/dvwhXXvFiNg?si=BUb-f5rBncgADinx
Curr Opin Pharmaco…
2 years, 7 months ago
BioiMedical Portrait III. NLRP3 Inflammasome and senescence-associated heterochromatic foci in macrophages, Kuppfer Cells and Liver sinusoidal endothelial cells contibute to liver/adipose disease
References
Telemann Georg P. 1765. Overture D Major, TWV 55:D18 | Tafelmusik https://youtu.be/8r-IFLtN9x4?si=T2hp65oGT--dTivY
Leukemia 2020 volume …
2 years, 7 months ago
BioMedical Portrait III.c12. Senescent cells from aging and obesity obtain chronic hyperinflammation of adipose associated leucocyte infiltrates potentiating alternating systemic proliferation or PCD.
References
Haydn, Michael. 1760. Salve Regina in G MH32. https://youtu.be/u_Xjo5KJ3mg?si=kmKaaBJMvUgs_blX
Leukemia 2020. volume 34, pages 75–86
CELL…
2 years, 7 months ago
BioMedical Portrait III. AMPK regulation of ACC2 blocks MalCoA inhibition of CPTI allowing for fatty acid beta oxidation thus alleviating adipose obesity-induced macrophage pro-inflammation.DJGPhD.
References
Saint-Saens. C. 1886. Symphony 3 (avec orgue) OP.78
J Clin Invest. 2011 Dec 1; 121(12):4903–4915
Cell Metab. 2022 Dec 6; 34(12): 2036–2046…
2 years, 7 months ago