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BioMedical PortraitIV The Frontal Temporal Dementias. Tau and TDP43 proteinopathies as an introduction to the extended pathobiochemical event ontologies. DJGPhD.16.10.23.Authentic Biochemistry Podcast
References
Schubert, F. 1820. Rosamunde Overture. https://youtu.be/3Pc_LUItWQI?si=ZB3bsrmz3ReiJQdi
Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad…
2 years, 9 months ago
BioMedical Portrait IV. TDP43 is involved in numerous pathologies that connect to the major cellular mechanisms governing DNA RRR, RNA metabolism and protein mediated cell fate. DJGPhD.14.10.23
Mol Cell Biol. 2012 Jan;32(1):126-38
Mutat Res. 2013 Jul-Sep;753(1):24-40
Molecular Neurobiology 2022. volume 59, pages 4223–4241
2 years, 9 months ago
BioMedical Portrait IV c8. Proteolytic processing of cytosolic RNA-bp ,TDP43, associates with CNS neuropathologies while native nuclear translocation is linked to exon shuffling. DJGPhD.12Oct23.
References
Molecular Neurobiology 2022. volume 59, pages 4223–4241
Hum Genet. 1994 Jan;93(1):67-73
Mol Cell Biol. 2012 Jan;32(1):126-38
2 years, 9 months ago
BioMedical Portrait IV c7.Progranulin associated frontotemporal lobar degeneration and AD, PD, and LBD, share a TDP-43 proteinopathy linked to mRNA translation. DJGPhD.11OCT23. Authentic Biochemistry
References
The EMBO Journal (2022)41:e109108
Acta Neuropathol. 2007 Sep;114(3):221-9
Acta Neuropathol.2013 Jul; 126(1): 51–57
Brain 2008. Volume 131,…
2 years, 9 months ago
BioMedical Portrait IV. c6. Proteinopathies in neurodegeneration may be the result of insufficient temporal control over microglial phagocytic and pro-inflammatory molecular event ontologies.DJGPhD
References
Brooker, G; Fisher, M and Reid, K. Procol Harum 1967. A Whiter Shade of Pale. https://music.youtube.com/watch?v=z0vCwGUZe1I&si=4iY2IY06x74…
2 years, 9 months ago
BioMedical Portrait IV.c5. Microglial removal of lipoprotein and proteinopathic molecular events must include lysosomal degradation and antigen presentation while supporting signaling and inflammation
References
Mozart, WA. 1791. Clarinet Concerto in A major, K. 622 https://youtu.be/YT_63UntRJE?si=bXBDcxTxsY1PxJa5
Small GTPases. 2014; 5: e28579
…2 years, 9 months ago
BioMedical PortraitIVc4. Microglial Rho GTPases equipped with GGylation, palmitoylation and/or phosphorylation obtain a spectrum of biochemical functions in neuropathologies.DJGPhD.8Oct23b. Authentic.
References
Mol Biol Cell. 2001 Sep; 12(9): 2711–2720.
Small GTPases. 2014; 5: e28579.
Cells. 2021 Jul 20;10(7):1831.
J Investig Med. 2023 Feb;71(2…
2 years, 9 months ago
BioMedical Portrait IV. c3. Two down-regulated microglial polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy distinct LDL binding proteins typically cargo oxy cholesterol.
References
Sinatra, Frank. timeless. My Way. https://youtu.be/qQzdAsjWGPg?si=TcpVOHDikKyyQdmC
Acta Neuropathol. 2023 Jun;145(6):749-772
Signal Transd…
2 years, 9 months ago
BioMedical PortraitIV.NHD patient fibroblasts used to generate iPSC's differentiated into Induced microglia like cells (iMGLs) pathophenocopied TREM2 mutations and lysosomal malfunctions.DJGPhD.
References
Neurol Genet. 2018 Jan 18;4(1):e211.
J Immunol (2003) 171 (2): 594–599.
Acta Neuropathol. 2023; 145(6): 749–772.
2 years, 9 months ago
BioMedical Portrait IV. HLA disease including neuropatholgies. The Nasu-Hakola, a.k.a. polycystic lipomembranous osteodysplasia associated TREM2 disease. DJGPhD.04Oct2023.Authentic Biochemistry.
References
Neurology. 2020 Jul 7; 95(1): e46–e58
Acta Neuropathol. 2023; 145(6): 749–772.
2 years, 9 months ago