Podcast Episodes

BioMedical Portrait I. 13b. 25 hydroxy cholesterol controling SREBP is linked toinflammation and the regulation of potentiating estrogen mediation over AD in post menapausal women.DJGPHD.18.8.23

References

Immunity 2021. 54, 2273–2287

Front Immunol. 2020. 11: 784

2 years, 9 months ago

Biomedical Portrait I, 13. Receptor boud 17Beta-estradiol may overturn the the failure to synthesize cholesterol in CNS caveolae thus blocking release of Beta-secretase to generate A-beta from APP.

__

[Mol Neurobiol] 2020 Jun; Vol. 57 (6), pp. 2654-2670

Oncol Rep. 2023 May;49(5):93

2 years, 9 months ago

BioMedical Portraits I. Chapter 12. Unique lipoprotein lipase mediated lipid alteration of endothelial cell function in the mammalian CNS may traffick in oxysterol binding protein linked PM-female AD

References

Steroids. 2022 Sep;185:109053

Trends Neurosci. 2015 Jun; 38(6): 364–374

Progress in Molecular Biology and Translational Science
Volume 168…

2 years, 9 months ago

BioMedical Portraits I. [11]. Phospholipid and lipoprotein lipase activity may link to oxy-cholesterol/PL transport mechanisms to generate post-menopausal AD. DJGPhD.16.8.23. Authentic Biochemistry

References

Histol Histopathol. 2018 Jan; 33(1): 1–10

J Steroid Biochem Mol Biol. 2022Feb;216:106040

Steroids. 2022 Sep;185:109053

2 years, 9 months ago

BioMedical PortraitI-10. Sterol binding protein and oxysterols regulate membrane fusion and trafficking obtaining a complex landscape for post menopausal estrogen assoc. neurodegeneration.DJGPhD.

References

J Steroid Biochem Mol Biol. 2022. Feb;216:106040.

Steroids. 2022 Sep;185:109053

2 years, 9 months ago

BioMedical PortraitsI.9. The 27-hydroxychol association with estrogen receptors and LXR provide contrarion associations with female AD and immune-controlled bacterial pathophysiology.DJGPhD.14.8.23

References

Alzheimer's Research & Therapy 2021. volume13, Article number: 56.

Progress in Molecular Biology and Translational Science 2019. Volume 1…

2 years, 9 months ago

BioMedical Portrait I. Chapter 8. Female AD progression post-menopausal severity is a complex pathobiochemical event that may involve cholesterol and steroid metabolism in the CNS and periphery.DJGPhD

References

Genes & Immunity 2021 volume 22, pages 125–140

Arch Endocrinol Metab. 2022 Jan-Feb; 66(1): 77–87

Essays Biochem. 2021 Nov; 65(6): 913–925

2 years, 9 months ago

BioMedical Portraits I. Chapter 7. Hormone replacement and the general distinctions of cholesterol homeostasis, metabolic zonation, hydroxysterols and estrogen receptor heterogeneity in female AD.

Reference

Journal of Cognitive Neuroscience (2022)34 (8): 1500–1520

2 years, 9 months ago

BioMedical Portraits I. Chapter 6. Complications of female cerebrovascular trauma and obesity-linked Type2 Diabetes in post-menopausal estrogen therapeutics for prophylactic treatment of subsequent AD

References

Mol Neurobiol 2020 Jun; Vol. 57 (6), pp. 2654-2670

Brain Res. 2009 Sep 22; 1290: 1–11.

JAMA.2003;289(20):2651-2662.

2 years, 10 months ago

Biomedical Portraits I. Part 5. 17-beta estradiol monotherapy in post-menopausal women has no irrefutable therapeutic benefit for treating cognitive decline in early AD dementia.DJGPhD.8AUG23.AB.

References

JAMA.2003;289(20):2651-2662.

Essays Biochem. 2021 Nov; 65(6): 913–925

Biol Psychiatry. 2019 Sep 15;86(6):421-432

2 years, 10 months ago