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Dose Proportionality (Ep. 37)
Episode 37
In this episode I talk about dose proportionality, which is a surrogate for determining if we have linear clearance across a range of dose levels. I …
1 year, 6 months ago
Covariate Search Methods (Ep. 36)
Episode 36
This episode is a discussion of covariate search methods. I give definitions of covariates and predictors, and then I describe 3 different covariate …
1 year, 6 months ago
Stimulatory Indirect Response PK-PD Models (Ep. 35)
Episode 35
In this episode I describe stimulatory indirect response PK-PD models. I describe how they work, how to set up the dataset for NONMEM, and how to cod…
1 year, 7 months ago
Inhibitory Indirect Response PK-PD Models (Ep. 34)
Episode 34
In this episode I describe inhibitory indirect response PK-PD models. I describe how they work, how to set up the dataset for NONMEM, and how to code…
1 year, 8 months ago
Effect compartment PK-PD models (Ep. 33)
Episode 33
In this episode I describe effect compartment PK-PD models. I describe how they work, a method of creating exploratory plots, how to set up the datas…
1 year, 8 months ago
Direct effect PKPD models (Ep. 32)
Episode 32
In this episode I describe direct effect PK-PD models. I describe how they work, a method of creating exploratory plots to identify direct effect mod…
1 year, 8 months ago
What should you use to present PK results? (Ep. 31)
Episode 31
In this episode I discuss different methods of presenting pharmacokinetic and pharmacometrics results. I spoke about using PowerPoint and R Markdown …
1 year, 9 months ago
How important is terminal rate constant? (Ep. 30)
Episode 30
This episode covers the terminal elimination rate constant calculated using non-compartmental analysis techniques. I reviewed how the rate constant i…
1 year, 10 months ago
Parellelization in modeling (Ep. 29)
Episode 29
This episode covered parallelization in modeling analyses. I spoke about across model parallelization and within model parallelization. I recommended…
1 year, 10 months ago
Residual errors and submission packages (Ep. 28)
Episode 28
Today I covered 2 different topics. First, I spoke about residual error models when modeling. I discussed additive, proportional, and power models. I…
1 year, 11 months ago