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Using R Shiny for Clinical Pharmacology (Ep. 47)
Episode 47
In this episode I discuss R Shiny and how it can be used for building clinical pharmacology tools. I provide an overview of the technology, suggest a…
9 months, 3 weeks ago
What is useful about noncompartmental analysis? (Ep. 46)
Episode 46
In this episode I discuss noncompartmental analysis. I categorize PK parameters calculated by NCA methods as either Important, Useful, or Questionabl…
11 months ago
How to select a base PK model (Ep. 45)
Episode 45
In this episode I review the process I follow for fitting a base pharmacokinetic (PK) model. I talk from the perspective of an individual PK model, b…
11 months, 4 weeks ago
Different estimation methods used in modeling (Ep. 44)
Episode 44
In this episode I discuss different algorithms used for pharmacometrics modeling. I describe difference between maximum likelihood and expectation ma…
1 year, 1 month ago
What is consulting life like? (Ep. 43)
In this episode I discuss my experience as an independent consultant in the clinical pharmacology and pharmacometrics space. I talk about how I got f…
1 year, 2 months ago
Population PK modeling with nlmixr (Ep. 42)
Episode 42
In this episode I discuss using nlmixr for population PK modeling in R. I give an overview of the software package, describe the installation process…
1 year, 3 months ago
Sample size calculations (Ep. 41)
Season 41
In this episode I discuss power calculations using the R package PowerTOST. I gave an introduction to power calculations and the statistical premise.…
1 year, 3 months ago
Collaboration with BioTalk Unzipped (Ep. 40)
Episode 40
In this episode I share a couple short clips from my conversation with Chad Briscoe and Greg Austin from BioTalk Unzipped (www.biotalkunzipped.com). …
1 year, 4 months ago
Toxicokinetics (Ep. 39)
Episode 39
In this episode I discuss toxicokinetic analysis. This is the analysis of exposure data to support animal toxicology studies. I review the purpose of…
1 year, 5 months ago
Steady State (Ep. 38)
Episode 38
This episode is a discussion of steady state pharmacokinetics. Steady state occurs when the amount of drug input is equivalent to the amount of drug …
1 year, 6 months ago