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Trazodone vs. Doxepin vs. Melatonin: Comparing Alternatives for Sleep

In this episode, we explore a head-to-head comparison of trazodone, doxepin, and melatonin for treating insomnia when benzodiazepines are off the tab…

11 months, 2 weeks ago

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Beyond Monotherapy: Mixed Episode Management

In this episode, we explore the critical decision of when to add lithium or valproate to second-generation antipsychotics in mixed manic episodes. Sh…

11 months, 3 weeks ago

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Old Drug, New Perspectives: Disulfiram's and Addiction Medicine

In this episode, we explore a provocative argument for reconsidering disulfiram as a first-line treatment for alcohol use disorder. Could this decade…

11 months, 3 weeks ago

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Quetiapine vs. Lithium in Mixed Bipolar States

In this episode, we explore the complex pharmacological management of mixed mania, a challenging bipolar presentation affecting up to 40% of manic ep…

1 year ago

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Psychedelic-Assisted Therapy: Redefining Treatment

In this episode, we explore psychedelic-assisted therapy in clinical practice, examining how these treatments differ fundamentally from traditional p…

1 year ago

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Lurasidone's Therapeutic Window: Is Less More?

In this episode, we explore groundbreaking research revealing that lower doses of lurasidone (40-60mg) may be more effective for bipolar depression t…

1 year ago

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Beyond Black Box Warnings: Choosing Antipsychotics in Dementia

In this episode, we explore a compelling comparison between olanzapine and risperidone for managing behavioral symptoms in dementia patients. Are the…

1 year ago

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SSRIs and Psychedelics: Drug Interactions

In this episode, we explore the complex drug-drug interactions between psychedelics and psychiatric medications. Do SSRIs really blunt psychedelic ef…

1 year ago

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Standard vs. High Doses: Rethinking Bipolar Maintenance Treatment

In this episode, we challenge the conventional wisdom of "what gets them well keeps them well" by exploring groundbreaking Finnish research on bipola…

1 year ago

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Psychedelics and Brain Networks

In this episode, we explore how psychedelics like psilocybin disrupt the brain's default mode network, creating windows of neuroplasticity that corre…

1 year, 1 month ago

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