Podcast Episodes
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Bret Taylor of Sierra on AI agents, outcome-based pricing, and the OpenAI board
Episode 27
Bret Taylor, co-founder of Sierra and Chair of the OpenAI board, joins John for a pint to discuss the rapid shift toward an agentic future. In this e…
7 months, 1 week ago
Garrett Langley of Flock Safety on building technology to solve crime
Episode 26
Garrett Langley is the founder and CEO of Flock Safety, a public safety operating system that helps communities and law enforcement eliminate crime. …
7 months, 2 weeks ago
Reiner Pope of MatX on accelerating AI with transformer-optimized chips
Episode 25
Reiner Pope is the co-founder and CEO of MatX, designing specialized chips for Large Language Models. A former Google TPU architect, he joins John to…
7 months, 3 weeks ago
Stripe’s 2025 annual letter
Episode 24
The internet economy accelerated in 2025. The fastest-growing companies got even faster, agentic commerce and stablecoin payments started to kick int…
7 months, 4 weeks ago
Ramp founder Eric Glyman on the many ways AI is changing corporate spending
Episode 23
Eric Glyman is the cofounder and CEO of Ramp, the finance automation platform that now powers over 2% of all corporate spend in the US. He sits down …
8 months ago
Ben Thompson from Stratechery on AI ads, the end of SaaS, and the future of media
Episode 22
Ben Thompson, the internet’s premier tech analyst, joins John for a wide-ranging conversation on the mechanics of the internet economy. They discuss …
8 months, 1 week ago
Elon Musk on Space GPUs, AI, Optimus, and his manufacturing method
Episode 21
John Collison and Dwarkesh Patel sit down with Elon Musk to discuss why the future of AI isn’t on Earth, but in the "always sunny" vacuum of space. B…
8 months, 2 weeks ago
Julia DeWahl of Antares on building nuclear reactors for the US military
Episode 20
Julia DeWahl is the cofounder of Antares, a company developing nuclear micro-reactors for the US military and critical infrastructure. She sits down …
10 months, 4 weeks ago
Satya Nadella describes how lessons from Microsoft’s history apply to today’s boom
Episode 19
Satya Nadella, CEO of Microsoft, sits down with John to discuss the diffusion of AI inside the enterprise. He explains why “all your data at your fin…
11 months ago
Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
Episode 18
Dave Ricks, the CEO of Eli Lilly, the world's most valuable pharmaceutical company, sits down with John and Patrick to discuss the complex business o…
11 months, 1 week ago