Podcast Episodes

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

Episode 972

Emmett Shear, founder of Twitch and former OpenAI interim CEO, challenges the fundamental assumptions driving AGI development. In this conversation with Erik Torenberg and Séb Krier, Shear argues tha…

Published on 4 weeks, 1 day ago

Can America Win The AI Biotech Race Against China? | Lada Nuzhna & Elliot Hershberg

Episode 970

Two venture capitalists dissect why biotech burns billions while China runs trials in weeks—and why the next Genentech won't look anything like the last one. Elliot Hershberg reveals the "three horse…

Published on 1 month ago

The Frontier of Spatial Intelligence with Fei-Fei Li

Episode 969

Fei-Fei Li and Justin Johnson are pioneers in AI. While the world has only recently witnessed a surge in consumer AI, they have long been laying the groundwork for the innovations transforming indust…

Published on 1 month ago

Rocket Companies CEO: Here’s How to Fix the Housing Crisis

Episode 968

The Empire State Building took 110 days to build—today, changing a window would take two years. 

Alex Rampell (a16z) and Varun Krishna (Rocket CEO) expose how asset inflation turned housing from the A…

Published on 1 month ago

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

Episode 967

Grant Lee was told Gamma was "the worst idea ever heard" by an investor who hung up mid-Zoom—yet he built it to 100 million users and $100M ARR without spending a dollar on advertising.

While competit…

Published on 1 month ago

Michael Truell: How Cursor Builds at the Speed of AI

Episode 966

When four MIT grads decided to build a code editor while everyone else was building AI agents, they created the fastest-growing developer tool ever built. 

Cursor CEO Michael Truell joins a16z’s Marti…

Published on 1 month ago

a16z's State of Crypto: The $4 Trillion Milestone and What's Next'

Episode 965

The regulatory environment has completely inverted. Stablecoins are now a top 20 holder of US treasuries. Every major bank wants in. In a16z Crypto's 2025 State of Crypto report, Daren Matsuoka (Head…

Published on 1 month, 1 week ago

Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

Episode 964

Adam D’Angelo (Quora/Poe) thinks we're 5 years from automating remote work. Amjad Masad (Replit) thinks we're brute-forcing intelligence without understanding it.

In this conversation, two technical f…

Published on 1 month, 1 week ago

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

Episode 963

Priscilla Chan and Mark Zuckerberg join a16z’s Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate …

Published on 1 month, 1 week ago

Seeing The Future from AI Companions to Personal Software

Episode 962

Eugenia Kuyda, CEO of Wabi and AI pioneer behind Replika, joins Erik, Anish, and Justine to reveal how personal software will transform from a developer monopoly to a creative medium for all. She exp…

Published on 1 month, 1 week ago