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1.63 POLO, TITAN, & from ASCO: FDA Approval, Surrogate Endpoints, and Patient Experience
1.63 POLO, TITAN, & from ASCO: FDA Approval, Surrogate Endpoints, and Patient Experience

This week we cover some of the highlights from this year's ASCO annual meeting. We discuss the POLO study "Maintenance Olaparib for Germline BRCA-Mut…

7 years, 3 months ago

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1.62 Rates of Cancer Screening, BILCAP Outcry, Waterfall Plots and Response Rate, & Dr. Jeff Sharman
1.62 Rates of Cancer Screening, BILCAP Outcry, Waterfall Plots and Response Rate, & Dr. Jeff Sharman

We begin this episode by responding to listener feedback from episode 1.61's discussion of clinic appointment time and rates of cancer screening. We …

7 years, 3 months ago

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1.61 Postpublication Metrics of RCTs, PCP Appointment Time, Bortezomib, & Dr. Christopher Booth
1.61 Postpublication Metrics of RCTs, PCP Appointment Time, Bortezomib, & Dr. Christopher Booth

This week we cover three papers -- "Postpublication Metrics of Randomized Clinical Trials With and Without Null Findings" by Murray et al. in JAMA, "…

7 years, 3 months ago

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1.60 I-PREDICT, Flawed Phase I Trials, & the Cost of Drugs with Dr. Daniel Hartung
1.60 I-PREDICT, Flawed Phase I Trials, & the Cost of Drugs with Dr. Daniel Hartung

We revisit I-PREDICT, discuss the "Imputability of Adverse Events to Anticancer Drugs" (a letter published recently in the New England Journal of Med…

7 years, 4 months ago

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1.59 BONUS! Should Evidence Come with an Expiration Date? with Palmer Greene
1.59 BONUS! Should Evidence Come with an Expiration Date? with Palmer Greene

In this BONUS episode, we interview Palmer Greene, a fourth-year medical student at the University of Chicago Pritzker School of Medicine, on his rec…

7 years, 4 months ago

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1.58 Magic Mouthwash with Dr. Arjun Gupta & Precision Oncology with Dr. Talal Hilal
1.58 Magic Mouthwash with Dr. Arjun Gupta & Precision Oncology with Dr. Talal Hilal

This week we discuss three paired papers on precision oncology published in Nature Medicine and then, later in the episode, go in-depth on the implic…

7 years, 4 months ago

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1.57 BONUS! Control Arm Quality in RCTs Leading to Anticancer Drug FDA Approval with Dr. Talal Hilal
1.57 BONUS! Control Arm Quality in RCTs Leading to Anticancer Drug FDA Approval with Dr. Talal Hilal

In this BONUS episode, we interview Dr. Talal Hilal of the Mayo Clinic on his paper that was published today in JAMA Oncology, titled "Analysis of Co…

7 years, 4 months ago

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1.56 BONUS! Real World Data & the Search for Meaningful Cancer Care with Dr. Christopher Booth
1.56 BONUS! Real World Data & the Search for Meaningful Cancer Care with Dr. Christopher Booth

This BONUS episode is the recording of a Grand Rounds lecture that Dr. Christopher Booth of Queen's University in Kingston, Canada gave this morning …

7 years, 4 months ago

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1.55 Role of a Professional Society & More with Dr. Cliff Hudis of ASCO
1.55 Role of a Professional Society & More with Dr. Cliff Hudis of ASCO

This week we sit down with Dr. Cliff Hudis, the CEO of the American Society of Clinical Oncology, to discuss the role of a professional society, the …

7 years, 4 months ago

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1.54 Association of Patient Characteristics and Tumor Genomics with Clinical Outcomes & SABR-COMET
1.54 Association of Patient Characteristics and Tumor Genomics with Clinical Outcomes & SABR-COMET

In this week's episode, we break down two recently published papers. The first is "Association of Patient Characteristics and Tumor Genomics With Cli…

7 years, 4 months ago

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