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Zachary DiMattia and Dave Feldman Debate LDL, Keto-CTA and Lean Mass Hyper-Responders
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In this episode of The Feldman Protocol, what does emerging research actually reveal about cardiovascular risk in people who develop extreme LDL elevations on ketogenic diets — and how much remains genuinely unresolved? Zachary DiMattia (nutritional scientist, Penn State) joins Dave to discuss his published review on ketogenic diet–induced LDL elevations in normal-weight adults, presents preliminary findings from his controlled feeding study comparing low- and high-BMI responses to a ketogenic diet, and engages Dave in a frank debate over plaque progression data, the lipid hypothesis, and the novel regressor findings from the Keto-CTA cohort.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/54` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & key findings preview1:24 – Zachary's background intro5:02 – Path to nutrition research8:01 – Hashimoto's diagnosis journey13:27 – Elimination diet & gluten discovery21:49 – Interest in ketogenic LDL response26:03 – Penn State controlled feeding study design34:12 – Preliminary study results41:40 – Review paper overview51:04 – Lipid hypothesis steel-man debate1:05:49 – LMHR phenotype & clinical context1:18:35 – Proposed mechanisms beyond LEM1:26:14 – Keto-CTA plaque progression data1:40:41 – Regressor findings & noise floor1:49:09 – Miami Heart match analysis2:03:50 – Mechanisms: adiposity & cholesterol2:14:52 – Nature CT study comparison2:43:29 – Audience questions & closing thoughts#FeldmanProtocol #DaveFeldman #ZacharyDiMattia #LeanMassHyperResponder #KetogenicDiet #LDLCholesterol #Cardiovascular #Atherosclerosis #LipidResearch #NutritionalScience #CholesterolResearch #PlaqueProg #KetoCTA #LipidEnergyModel #Cardiometabolic #LowCarbResearch #Bloodwork #HeartHealth