Episode Details

One in eight adults report feeling exhausted almost every day for months at a time — and for women 18-44, it's closer to one in five. That's the jumping-off point for this episode, where Dr. Kylie Burton and Jessica Brickie tackle a molecule that shows up on nearly every peptide company's menu, even though it isn't technically a peptide at all: NAD+.

The hosts break down what NAD+ actually is (a dinucleotide, not a peptide), why it gets grouped in with peptide therapy anyway, and the two jobs it does at the cellular level — powering ATP production and driving DNA repair. From there, the conversation moves into why NAD+ levels decline starting in your 20s, what the current research does and doesn't support, and why delivery method (IV, subcutaneous injection, or nasal spray) makes or breaks whether it actually works. Along the way, Kylie shares her own first-time, slightly nerve-wracking experience trying NAD+ nasal spray at a wellness convention in Texas — burn and all — and what she noticed in the hours afterward.

This one comes with an upfront disclaimer worth calling out: neither host holds prescribing rights, and the conversation is explicit that this isn't medical advice, chronic fatigue can have other root causes, and any decision on whether NAD+ is right for you belongs with a licensed provider.

What You'll Learn

• Why NAD+ isn't a peptide — and why it still lives in the same conversation and the same clinics
• The two core jobs NAD+ does inside every cell: energy production (ATP) and DNA repair
• What sirtuins are and why the longevity space pays so much attention to them
• Why NAD+ levels start declining in your 20s — and what that decline feels like by your 40s, 50s, and 60s
• What the current research actually shows: strong animal data, more mixed human clinical data
• Why delivery method matters — why oral NAD+ largely doesn't work, and why IV, subcutaneous, and nasal spray routes are used instead
• Kylie's first-time nasal spray experience at a peptide convention — and what changed the second time
• Why NAD+ feels different from caffeine: not a stimulant buzz, but "restoring the machinery" behind energy
• Who NAD+ tends to be a fit for: fatigue relief, longevity/anti-aging, and athletic recovery alongside peptides like BPC-157 and TB-500
• Important root-cause context: why chronic fatigue should be worked up with a provider first, since thyroid issues, anemia, blood sugar imbalances, sleep apnea, and autoimmune conditions can all mimic what NAD+ is being asked to fix

Segment Breakdown

• What NAD+ Actually Is — Nicotinamide adenine dinucleotide, why the "plus" matters, and why it's not a peptide
• Cellular Energy & ATP Basics — Mitochondria, ATP, and why NAD+ is non-negotiable for cell function
• DNA Repair & Why Levels Drop — Sirtuins, cellular stress, and the age-related decline starting in your 20s
• Research Reality & Medical Disclaimer — What the human trials actually show, and an honest disclosure about scope of practice
• Why Delivery Method Changes Results — Why oral NAD+ largely fails and what routes actually work
• The Texas Convention Nasal Spray Test — Kylie's real-time first experience trying NAD+
• Who NAD+ Is For — Fatigue, longevity, and athletic recovery, and how it pairs with peptide stacks

Where do you start with peptide therapy? What do you add next? If you're a go-getter, check out Dr. Kylie's new program AMPLIFY. You'll find it on the homepage of her website: drkylieburton.com

Ready to explore peptide therapy for yourself? Join through Jessica's platform at B2BwithJess.com/peptides or through Dr. Kylie's platform