Episode Details

Cells are constantly receiving information not only through chemical messengers such as hormones, neurotransmitters, and growth factors, but also through their physical environment. In this episode, we explore integrins: specialized cell-surface receptors that help link the extracellular matrix to the cell’s internal scaffolding. I discuss how integrins participate in adhesion, movement, cellular organization, and mechanosensing and why a cell’s local environment, including matrix composition, structure, stiffness, and loading, can influence its behavior.  All this gives us one more reason to keep fascia healthy!

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References mentioned:

Anderson, L. R., Owens, T. W., & Naylor, M. J. (2014). Structural and mechanical functions of integrins. Biophysical reviews, 6(2), 203–213. https://doi.org/10.1007/s12551-013-0124-0

Fagerholm S. C. (2022). Integrins in Health and Disease. The New England journal of medicine, 387(16), 1519–1521. https://doi.org/10.1056/NEJMcibr2209679