Guest:
Dr. Roger Geiger is a Group Leader at the Institute for Research in Biomedicine in Bellinzona, Switzerland, and leads a research group at the Technical University of Dresden in Germany. He discusses how his lab studies the metabolic regulation of T cell function and explores engineering bacteria to deliver therapeutic payloads directly to tumors. He also explains how arginine metabolism can enhance anti-tumor T cell responses and how naïve T cells remain metabolically prepared to rapidly respond to immune challenges.
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The Immunology Science Round Up
C. difficile Shapes Gut Development– Early-life C. difficile exposure alters intestinal stem cell behavior and leaves lasting changes in gut development.
The Serotonin–Asthma Connection– ILC2-derived serotonin amplifies airway inflammation and activates sensory neurons to promote asthma and cough hypersensitivity.
IgA Fuels Liver Inflammation – IgA binding to liver myeloid cells is associated with IL-1-linked inflammation and liver injury in alcohol-associated liver disease.
Serotonin Drives Severe COVID-19 – Platelet-derived serotonin promotes blood clotting and lung dysfunction during SARS-CoV-2 infection, helping explain greater disease severity with age.
Image courtesy of Dr. Roger Geiger