Episode Details

A listener with functional dyspepsia asks why dopamine-blocking drugs (like sulpiride and metoclopramide) kill his nausea but leave him exhausted the next day — and why his daily ADHD stimulant never makes him nauseous at all. We trace the area postrema, the brain's blood-barrier-free chemoreceptor trigger zone, and explain why nausea and vomiting aren't the same thing, why D2 blockade is both the cure and the side effect, and what separates a drug that crosses into the brain from one that stays in the gut. Plus: why metoclopramide has been the only FDA-approved gastroparesis drug since 1979, and what the tardive dyskinesia black box warning actually means for long-term use. Episode #181585 — open it directly at myweirdprompts.com/181585