Episode Details
Back to EpisodesFurin, Naturally with Paul Bieinasz
Description
Paul Bieniasz joins TWiV to discuss his lab's discovery that the coronavirus nuclease NSP15 cuts viral RNA into oligonucleotides that are reinserted elsewhere in the viral RNA, generating insertion mutations at a frequency above 10⁻³ per genome, including new furin cleavage sites at the spike S1/S2 junction.
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Links for this episode
- Support science education at MicrobeTV
- Genetic innovation in coronaviruses driven by a viral nuclease (bioRxiv)
- Letters read on TWiV 1357
- Timestamps by Jolene Ramsey. Thanks!
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