Episode Details

In today's episode we're diving into how caloric restriction can slow down the biological aging process and silence chronic inflammation. We explore groundbreaking human research showing that cutting calories deactivates key complement immune pathways, specifically targeting complement C3a.

Discover the surprising role that visceral fat plays in driving systemic inflammaging through specialized macrophages that trigger age-related inflammation. We also break down how autocrine signaling in immune cells accelerates aging and share practical, actionable insights on how metabolic tweaks can protect your healthspan and promote healthy aging over time.

=== REFERENCES ===

• https://doi.org/10.1038/s43587-026-01107-0
• https://doi.org/10.5281/zenodo.18805277

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This episode includes AI-generated content.