Episode Details

Science fiction is full of superpowered mutants, but in reality, mutations are much more diverse and complex. Sometimes, they can change someone’s entire body, and other times, we don’t notice them at all! In this episode, we’ll unpack what mutations are, how they work (including substitutions and frameshift mutations), and how scientists are learning to control mutations using tools like CRISPR/Cas9 and gene therapy.

Introduction: Mutations Outside the Movies 00:00
What Are Mutations? 1:20
What Determines Mutations' Effects? 3:10
Types of Mutations 4:16
Positive, Negative, or Neutral? 7:43
Gene Therapy & CRISPR 8:23
Pharmacogenomics 10:59
Review & Credits 11:58

This series was produced in collaboration with HHMI BioInteractive, committed to empowering educators and inspiring students with engaging, accessible, and quality classroom resources. Visit https://BioInteractive.org/CrashCourse for more information.

Are you an educator looking for what NGSS Standards are covered in this episode? Check out our Educator Standards Database for Biology here: https://www.thecrashcourse.com/biologystandards

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Watch this series in Spanish on our Crash Course en Español channel here: https://www.youtube.com/playlist?list=PLkcbA0DkuFjWQZzjwF6w_gUrE_5_d3vd3

Sources: https://docs.google.com/document/d/1GLDtAXE6ekg4Chk2qN3TYbNt0pJbyaHqTqRd6QY8pd4/edit?usp=sharing

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