Episode Details

New weight-loss drugs like Ozempic and Wegovy are revolutionizing how people lose weight—delivering dramatic results for many—but for up to a third, the effects are minimal. Scientists are racing to uncover why, exploring genetics, age, sex, and even ancestry as potential factors. For those who don’t respond, it’s emotionally and financially draining—but it’s not their fault. Emerging research points to genetic resistance, where bodies simply don’t react as expected. While we can’t yet predict who will benefit, the science is evolving, with new treatments and even surgery on the horizon. It’s about biology, not effort.

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