Episode Details

Dr. G explores how the tiny nematode C. elegans helps researchers study key processes related to diabetic foot ulcers, including wound detection, calcium signaling, cytoskeletal remodeling, mitochondrial reactive oxygen species, innate immune responses, and bacterial virulence.

While the worm cannot reproduce the full complexity of human diabetic foot disease, its transparency and genetic tractability make it a powerful early-stage model to identify pathways and test hypotheses that could inform future treatments.