Episode Details

Drug adherence and persistence measures built from claims or EHR databases depend as much on study definitions as recorded treatment events. In this QCast episode, co-hosts Jullia and Tom explain how adherence differs from persistence, what prescribing and dispensing data can and cannot show, and how MPR, PDC, treatment-gap rules and thresholds shape the findings.

Key Takeaways

• Adherence describes how closely medicine use follows the agreed regimen, while persistence measures how long treatment continues before discontinuation.
• Claims and EHR data provide useful evidence on prescriptions, dispensing and treatment changes, but neither confirms that a patient took the medicine as intended.
• MPR, PDC and persistence estimates depend on decisions about follow-up, days’ supply, permissible gaps, dose changes, switching and censoring.

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📝 Episode Notes & Transcript: Find show notes, resources, and a full transcript at quanticate.com/podcast.
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About Quanticate

Founded in 1994, Quanticate is a biometrics-focused CRO with over 30 years' experience delivering expert clinical and post-marketing data services worldwide. Specialising in the collection, management, standardisation, analysis, and reporting of data, we support pharma and biotech companies globally with high-quality solutions for clinical development. We specialise in:

• Clinical Data Capture & Management
• Biostatistics & Statistical Consultancy
• Statistical Programming & PK/PD Analysis
• Medical Writing & Pharmacovigilance
• Regulatory & Submission Support
• AI & Automation
• Post-Marketing Safety & Real-World Data

Quanticate is committed to delivering expertise and solutions that drive the success of clinical development worldwide.