Episode Details

What if the key to beating cancer wasn't a new drug, but a new way of thinking about matter itself? That's the question Laurent Lévy asked when he co-founded Nanobiotix over twenty years ago — and it's a question that is now producing some genuinely compelling answers in the clinic.

Nanobiotix is a Paris-based biotech pioneering what they call physics-based nanomedicine. Their lead asset is a radioenhancer made of hafnium oxide nanoparticles, designed to be injected directly into a tumor and amplify the destructive power of radiotherapy from within — without increasing damage to surrounding healthy tissue. It is currently in Phase 3 trials in head and neck cancer.

But that's only half the story. The company's Nanoprimer platform is now emerging as a potential new engine for growth — with the promise of making an entirely new class of genetic medicines work better.

• 02:47 Meet Laurent Lévy
• 06:04 What physics offers that biology cannot 
• 11:12 How JNJ-1900 (NBTXR3) works 
• 15:14 The immune effect 
• 18:16 Pipeline milestones ahead
• 20:56 The Curadigm Nanoprimer platform 
• 25:32 The oversubscribed €85 million raise

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To dive deeper into the topic: 

• Radiotherapy-Enhancing Cancer Nanomedicine Secures Good Phase II/III Results
• Get to know 15 of the best biotech companies in Paris
• Eight nanotechnology companies to watch out for