Episode Details

This episode explores SMAPs — synthetic mimics of antimicrobial peptides — and how they use membrane-targeting chemistry to kill bacteria differently from conventional antibiotics.

It covers the science behind facial amphiphilicity, selectivity versus toxicity, challenges like biofilms and stability, and the potential role of SMAPs as future adjunctive topical therapies for diabetic foot ulcers, while emphasizing they remain experimental and not yet clinical standard of care.