Episode Details

The Filtrate:

Joel Topf

Swapnil Hiremath

Jennie Lin (who was only there because her plans got boxed by covid)

Jordy Cohen

Josh Waitzman

Special Guest:

Rajiv Agarwal (@AgarwalRajivMD)

Editor:

Joel Topf

Show Notes:

NephJC discussion of CLICK: http://www.nephjc.com/news/click4chlorthalidone

CLICK Visual abstract: http://www.nephjc.com/news/2021/12/7/the-click-visual-abstract

Hawthorne effect: https://en.wikipedia.org/wiki/Hawthorne_effect

A nice discussion run in periods in clinical trials: http://www.nephjc.com/news/run-in-period

The ABCD trial Agarwal used to describe the need for a beta blocker to enroll in the trial, but it looks like a review article https://pubmed.ncbi.nlm.nih.gov/12574784/

Canadian trial showing that atenolol did as well as evidence based beta blockers: https://pubmed.ncbi.nlm.nih.gov/31495887/ Associated editorial by Agarwal: https://pubmed.ncbi.nlm.nih.gov/31578572/

Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate by Mark A Peterzan https://pubmed.ncbi.nlm.nih.gov/22547443/

HCTZ vs Chlorthalidone compete to the death: VA CSP Study No. 597: Diuretic Comparison Project https://www.research.va.gov/programs/csp/597/default.cfm

Effectiveness versus Efficacy Trials: https://www.ncbi.nlm.nih.gov/books/NBK44024/

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