Episode Details
Back to Episodes15 High-Protein Food Swaps for Weight Loss on GLP-1 Medications (Zepbound)
Description
#GLP1 #Ozempic #wegovy #WeightLoss #HighProteinDiet
Eating less on Ozempic, Wegovy, Mounjaro, or Zepbound doesn't automatically mean your diet is helping you lose fat. In this video, hospitalist physician Dr. Mohammed Paika breaks down 15 real grocery-aisle swaps — each evaluated for calories, fat, and carbohydrate quality, not just protein — along with the clinical research on why protein and muscle preservation matter so much while you're on a GLP-1.
0:00 Intro — Why "Eating Less" Isn't Enough on a GLP-1
0:55 Who I Am (Hospitalist Physician, Not an Influencer)
2:40 The Patient I Think About
3:53 Why Protein Isn't Optional on a GLP-1
8:46 15 Swaps: How to Shop Smarter (Start Here)
10:16 Swap 1: Frozen Peas & Corn vs. Edamame
10:52 Swap 2: White Rice vs. Lentils
11:31 Swap 3: Regular Ice Cream vs. High-Protein Ice Cream
12:16 Swap 4: Breaded Chicken Tenders vs. Tempeh
12:47 Swap 5: Granola Bar vs. Protein Bar 13:51 Swap 6: Croutons vs. Roasted Chickpeas 14:28 Swap 7: Mayonnaise vs. Hummus
15:07 Swap 8: Tuna in Oil vs. Tuna in Water
15:44 Swap 9: Breaded Fried Fish vs. Baked Salmon
16:23 Swap 10: Fried Chicken vs. Rotisserie Chicken
16:57 Swap 11: Whole-Milk vs. Part-Skim Mozzarella
17:27 Swap 12: Regular vs. Powdered Peanut Butter
18:13 Swap 13: Whole Milk vs. Ultra-Filtered High-Protein Milk
18:52 Swap 14: Fruit Smoothie vs. Protein Shake
19:39 Swap 15: All-Beef Tacos vs. Turkey & Black Bean Tacos
21:59 Why Muscle Is the Organ of Longevity
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References
Look, M., et al. "Body Composition Changes During Weight Reduction with Tirzepatide in the SURMOUNT-1 Study." Diabetes, Obesity and Metabolism, 2025.
Neeland, I.J., et al. "Changes in Lean Body Mass with GLP-1-Based Therapies and Mitigation Strategies." Diabetes, Obesity and Metabolism, 2024.
The Obesity Society. Clinical guidance on protein intake (1.2–1.6 g/kg/day) during active weight loss.
"Higher Protein Intakes Predict Leaner Body Composition in Weight-Loss Participants." International Weight Control Registry, 2024–2025.
"Effects of Varying Protein Amounts and Types on Diet-Induced Thermogenesis: A Systematic Review and Meta-Analysis."
Leidy, H.J., et al. "Effects of Consuming Frequent, Higher Protein Meals on Appetite and Satiety During Weight Loss in Overweight/Obese Men." Obesity (Silver Spring), 2011.
"Dietary Recommendations for the Management of Gastrointestinal Symptoms in Patients Treated with GLP-1 Receptor Agonists."
"Clinical Recommendations to Manage Gastrointestinal