Episode Details

Methylation has become one of the hottest topics in functional medicine, biohacking, and wellness. From MTHFR testing to methylated supplements, many people are being told that boosting methylation is the key to better energy, mood, detoxification, hormone balance, and longevity.

But what if more methylation isn't always better?

In this episode, Joanne explores the science behind methylation, the roles of MTHFR and COMT, and why relying solely on genetic reports can lead to inappropriate supplementation. Joanne explains the difference between undermethylation and overmethylation, the symptoms of excess methyl groups, and why many people experience worsening anxiety, insomnia, irritability, and other adverse effects when taking methylated supplements.

Whether you're a practitioner, student, or someone navigating histamine intolerance, hormone imbalances, or chronic health concerns, this episode provides a balanced, evidence-informed perspective on one of today's most talked-about health trends.

In this episode, you'll learn:

• What methylation is and why it's essential for health
• How methylation affects neurotransmitters, hormones, detoxification, and gene expression
• The difference between undermethylation and overmethylation
• The role of MTHFR, COMT, folate, and vitamin B12 in methylation pathways
• Common symptoms of excess methyl groups
• Why genetic testing alone doesn't tell the whole story
• The potential risks of methylated supplements
• A more personalised approach to methylation support

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📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!

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