Episode Details

How does splitting a Vyvanse dose actually change your blood concentration curve? We dive deep into the pharmacokinetics of lisdexamfetamine, a prodrug that converts to dextroamphetamine in your red blood cells. We explore the science behind water titration, the impact of stagger intervals (two, four, or six hours), and why a three-part split might create a smoother plateau than a single dose. We also discuss the tools available for modeling your personal curve, the surprising effect of urinary pH on half-life, and why your psychiatrist might be onto something with this experimental dosing protocol.