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Covid infection did not increase incidence of post-covid myocarditis or pericarditis. The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients-A Large Population-Based Study https://pubmed.ncbi.nlm.nih.gov/35456309/ https://www.mdpi.com/journal/jcm Myocarditis and pericarditis, post-acute cardiac sequelae of COVID-19 infection, arising from adaptive immune responses. ? incidence Retrospective cohort study Study group, had infection N = 196,992 adults after COVID-19 infection (Clalit Health Services) March 2020 to January 2021 Inpatient myocarditis and pericarditis diagnoses, from day 10 after positive PCR Israeli vaccination program initiated on 20 December 2020 Follow-up was censored on 28 February 2021 Control cohort, never infected N = 590,976 adults, with at least one negative PCR and no positive PCR (age- and sex-matched) Calculated backward from 15 December 2020 Results Post-COVID-19 group Nine post-COVID-19 patients developed myocarditis (0.0046%) Eleven diagnosed with pericarditis (0.0056%) Control group, never covid infected 27 developed myocarditis (0.0046%) P = 1 52 developed pericarditis (0.0088%) P = 0.17 Adjusted hazard ratio [aHR] Myocarditis, male (aHR 4.42) regardless of previous COVID-19 infection Pericarditis, (aHR 1.93) Peripheral vascular disease, (aHR 4.20) Follow up Median, 4.1 months Covid cohort, 700,040 person-months Non covid cohort, 2,100,077 person-months Conclusions Post COVID-19 infection was not associated with myocarditis (aHR 1.08) Post COVID-19 infection was not associated with pericarditis (aHR 0.53) We did not observe an increased incidence of neither pericarditis nor myocarditis in adult patients recovering from COVID-19 infection. Our data suggest that there is no increase in the incidence of myocarditis and pericarditis in COVID-19 recovered patients, compared to uninfected matched controls.

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