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The Mitochondria Problem Behind Aging Skin + How Recharge Your Skin and Look Younger
Description
Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants of a free-living bacterium swallowed by a larger cell 2 billion years ago. As you age, those mitochondria run slower and your cells build fewer of them to replace the ones that fail.
In this solo episode, Young Goose co-founder Amitay Eshel breaks down the two sides of mitochondrial decline that drive skin aging and explains why the science-led skincare category has spent the last decades addressing only one of them.
The first side of skin aging is where most skincare brands have built their products around. The other side is the one almost no skincare on the market is formulating for, and it is where the next chapter of skin longevity is being written.
If you have outgrown the antioxidant-and-peptide era of skincare and want to understand what is actually happening underneath your skin as it ages, this episode is for you.
What's Discussed:
(01:35) The 2-billion-year-old contract inside every skin cell that is now fraying.
(04:10) Why skin is one of the most mitochondria-dense organs in your body.
(08:20) The 2012 paper that showed NAD drops by half between 35 and 70.
(13:15) How a refugee fired in 1933 figured out the chemistry your cream still runs on.
(16:30) The second half of the decline almost no skincare addresses.
(19:45) The master regulator that decides whether your cells can hire.
(24:00) The two columns of mitochondrial biology and why most brands only work in one.
(32:10) Why this is a ten-year strategy, not a two-week one.
Resources Mentioned:
Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/
FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare