Episode Details

Today, we are talking about a true paradigm shift in prenatal genetics. For decades, we’ve relied on cell-free DNA for screening, but when it came to definitive confirmation of fetal aneuploidy, we’ve had to counsel our patients through the anxiety and physical risks of invasive procedures like amniocentesis and CVS. But what if the line between screening and confirmation just blurred? In this episode, we are diving into an avant-garde, first-of-its-kind maternal blood test that is now actively in clinical use and may prove to rival traditional invasive testing for fetal aneuploidy confirmation: the Unity CONFIRM test. To break down the cutting-edge science, the clinical validity, and exactly what this means for your daily practice, I am thrilled to welcome Jen Hoskovec, the Vice President of Medical Affairs for BillionToOne. You might have recently seen her insights featured alongside Dr. Haywood Brown in Contemporary OB/GYN, and today, she’s here with us. We’re going to discuss the availability of this test, the technology that makes it possible, and what the next concrete steps are for integrating this into modern obstetrical care. Grab your coffee. Let’s get into the science.

1. https://www.contemporaryobgyn.net/view/haywood-brown-md-jennifer-hoskovec-explain-new-non-invasive-confirmatory-test

2. Screening for Fetal Chromosomal Abnormalities PA; January 2026