Episode Details

Can aging be reversed, or slowed in a meaningful way.

This episode covers cellular reprogramming, OSK, Yamanaka factors, epigenetic aging, and the key studies behind the claims.

You will hear what the mouse data showed, what chemical reprogramming achieved in human cells, and where the science still has limits.

References:

• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
  The original 2006 iPS paper. It introduced the four factors Oct3/4, Sox2, c-Myc, and Klf4. Source
• Reprogramming to recover youthful epigenetic information and restore vision
  This Nature paper reported that OSK restored youthful DNA methylation patterns, promoted axon regeneration, and reversed vision loss in mouse models. Source
• Full text via PubMed Central for the OSK vision paper
  Useful if you want the full paper without a paywall. Source
• Chemically induced reprogramming to reverse cellular aging
  This paper reported six chemical cocktails that restored a youthful transcript profile in human cells in under a week, without changing cell identity. Source
• Full text for the chemical reprogramming paper
  Direct publisher link to the full study. Source
• Loss of epigenetic information as a cause of mammalian aging
  The Cell paper that lays out the epigenetic information loss model of aging. Source
• ClinicalTrials.gov listing, NCT07290244
  A ClinicalTrials.gov study page connected to this area of research. Source

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This episode includes AI-generated content.