Episode Details

A drug was approved in China

Then it failed clinical trials in the US

No one could figure out why

The answer was hiding in the gut microbiome
Anto Bio’s model helped identify it

99% of the genes in your body aren't yours 
They belong to your microbiome
Over two-thirds of drugs are heavily affected by how your gut processes them

But the microbiome data was too noisy. Too messy. Petabytes of it just sitting there

Anto Bio's mission: make the gut microbiome computable for the first time

They're building foundation models that help pharma design drugs that work for more people

🎙️ Arvid Gollwitzer, Co-Founder, Anto Bio on Fondo START pod

1:18 What Anto Bio is building and why it's novel

2:10 Why this didn't exist before

3:05 99% of your genes aren't yours

4:00 Why pharma ignoring the microbiome is a huge problem

5:04 The microbiome is modifiable

6:30 Modeling microbiome differences across populations

7:00 Drug approved in China, failed in the US, and how Anto found out why

8:02 How many drugs are affected by microbiome metabolism

10:00 GLP-1s and the gut microbiome connection

12:42 The biggest unsolved variable in drug development

Learn more at www.anto.bio