Episode Details

In this episode, Dr. Gladden and nutrition expert Sarah Kennedy discuss Calocurb, a natural extract that uses evolutionary biology to suppress appetite. The discovery focuses on bitter taste receptors (T2Rs) located throughout the gastrointestinal tract, which historically served as a protective mechanism to slow the consumption of potentially toxic substances. By using a specific New Zealand hop extract, Calocurb triggers these receptors to signal the brain that the body is full. This process stimulates the natural release of satiety hormones—GLP-1, CCK, and PYY—effectively quieting "hunger noise" and reducing caloric intake without the need for synthetic pharmaceuticals.

For Audience

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Takeaways

· Sarah Kennedy transitioned from veterinary medicine to nutrition.

· Calocurb is based on the hypothesis of appetite suppression through bitter taste receptors.

· Bitter taste receptors are present throughout the gastrointestinal tract.

· The primary hormones involved in appetite suppression are CCK, GLP-1, and PYY.

· Clinical studies showed an 18% reduction in calorie intake with Calocurb.

· Calocurb has a duration of action of four to six hours.

· 5% of users may experience a laxative effect as a side effect.

· The product can be used intermittently for weight management.

· Future research will explore the effects of Calocurb on adolescents and gut health.

· Calocurb is a natural alternative to synthetic appetite suppressants.

Chapters

00:00 Introduction to Calocurb and Sarah's Background

02:52 The Science Behind Appetite Suppression

05:56 Mechanisms of Action: Hormones and Receptors

08:55 Clinical Studies and Results of Ca