Episode Details

New study unveils how GLP-one oral weight loss drugs, like semaglutide and orforglipron, not only suppress hunger but also dampen pleasure-driven cravings by modulating the brains reward pathways. Researchers discovered that these pill versions of the drugs, which are cheaper and easier to produce, can light up the central amygdala, a deep brain region that reduces dopamine release during rewarding activities. This finding opens up the possibility of using these drugs to treat addictions beyond food, with experts considering tests for substance use disorders next.

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