Episode Details

This week we dive into the Beyond Biotech archive to bring you a discussion with Dr Stanley Qi, the founder of Epicrispr.

Epicrispr is an epigenetic editing company, leveraging the power of CRISPR without cutting DNA. The company’s proprietary Gene Expression Modulation System (GEMS) includes the smallest Cas protein known to work in human cells, enabling in vivo or ex vivo delivery via a single viral vector. 

In this episode we discuss epigenetic editing, why it’s reversible, and how it can treat FSHD and other conditions. 

• 01:43 Meet Stanley Qi
• 03:32 Founding Epicrispr
• 05:53 CRISPR interference and epigenome explained
• 10:04 Overview of GEMS gene modulation system
• 11:28 Reversibility and safety of epigenetic edits
• 18:42 Strategy for tackling multiple disease conditions
• 23:27 Clinical trial plans for EPI-321 candidate
• 30:06 Looking forward

This episode is brought to you with the support of MedChemExpress.

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To dive deeper into the topic: 

• Could CRISPR really cure these diseases?
• 10 gene therapy companies you should know about
• CRISPR technology’s next wave: Ten companies to watch