Episode Details

Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage. 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Sarah Daccarett, MD, a physician, longevity expert, and the founder and CEO of Inner Balance, a modern women's health company redefining hormone therapy, sexual wellness, and aging. She has treated tens of thousands of women across all 50 states and is known for challenging outdated medical models and building science-driven solutions that reflect female biology rather than borrowing protocols designed for men. She created Oestra, a revolutionary hormone therapy delivery system, along with Libida, an on-demand libido solution that targets desire at the brain level, making her one of the most credible and innovative voices in functional medicine and women's longevity today. 

Together, they expose why conventional medicine has failed women for decades, why patches and pills are nearly useless, and what actually works for anti-aging, metabolism, longevity, and human performance. Dr. Sarah makes the case that hormone replacement therapy is not a last resort for menopausal women. It is a foundational longevity strategy that every woman should consider starting in her 20s. 

You'll Learn: 

• Why vaginal hormone delivery outperforms every other delivery method for women 
• How low estrogen destroys your gut lining, gallbladder, and immune system long before menopause symptoms appear 
• Why a carnivore or animal-based diet raises estrogen and why fiber lowers it 
• How progesterone converts to testosterone in women, and why you may not need a testosterone prescription 
• The real reason SSRIs get prescribed when hormone replacement therapy should come first 
• Why iodine is essential for breast health, estrogen metabolism, and thyroid function 
• How oxalates from "superfoods" like matcha, spinach, and almonds accumulate in your ovaries, uterus, and kidneys 
• Why both partners need hormone replacement therapy for a relationship to thrive 
• How hormones control mitochondria, dopamine, norepinephrine, and every system in your body 

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take con