Episode Details

In this episode, we talk about progressive multiple sclerosis (PMS), including primary progressive MS (PPMS) and secondary progressive MS (SPMS). Neurologist Dr. Thomas Knoll shares insights from over 30 years of clinical experience, focusing on disease mechanisms, current treatment options, and what people living with progressive MS can actively do to maintain their quality of life.

💡 Note: This episode is based on an interview originally recorded in November 2023 and has been translated and adapted for an international audience.

A key takeaway: While neurodegeneration is still difficult to treat, an active lifestyle, symptom management, and strong support systems can make a meaningful difference.

👉 Read the full interview (English): https://ms-perspektive.com/161-pms

• What defines PPMS and how it differs from other MS types
• Typical symptoms and disease progression
• Current treatment options and limitations
• Role of B-cell therapies (e.g., Ocrelizumab)
• Importance of early intervention
• Rehabilitation, physiotherapy, and lifestyle factors
• How to maintain quality of life with progressive MS
• Patient support, networks, and resources
• Future research and treatment perspectives

Organizations & Support:

• German Multiple Sclerosis Society (DMSG): https://www.dmsg.de
• AMSEL (MS patient organization): https://www.amsel.de
• Multiple Sclerosis International Federation (MSIF): https://www.msif.org
• European Multiple Sclerosis Platform (EMSP): https://www.emsp.org

Recommended by Dr. Knoll:

• MS Selfie: https://msselfie.co.uk/

Further information & networks:

• NeuroTransData: https://www.neurotransdata.com
• NeuroTransConcept: